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Volume 15, Number 9—September 2009

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Phylogeny and Disease Association of Shiga Toxin–producing Escherichia coli O91

Alexander MellmannComments to Author , Angelika Fruth, Alexander W. Friedrich, Lothar H. Wieler, Dag Harmsen, Dirk Werber, Barbara Middendorf, Martina Bielaszewska, and Helge Karch
Author affiliations: Institute of Hygiene and the National Consulting Laboratory on Hemolytic Uremic Syndrome, Münster, Germany (A. Mellman, A.W. Friedrich, D. Harmsen, B. Middendorf, M. Bielaszewska, H. Karch); Department of Periodontolgy, Münster (D. Harmsen); Robert Koch Institute, Wernigerode, Germany (A. Fruth); Free University Berlin, Berlin, Germany (L.H. Wieler); Robert Koch Institute, Berlin (D. Weber)

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Table 2

Univariate associations of STEC O91 of sequence type 442 with severe disease by use of exact logistic regression*

Severe disease ST442, no. (%) Non-ST442, no. (%) Odds ratio 95% Confidence interval p value
HUS 4 (20) 0 (0) 27.8† 3.29–∞ <0.01
BD 3 (15) 5 (6) 3.4 0.47–20.1 0.25
HUS or BD 7 (35) 5 (6) 7.8 1.83–36.6 <0.01

*Reference group consisted of persons who had nonbloody diarrhea or who were asymptomatic carriers. STEC, Shiga toxin-producing Escherichia coli; ST, sequence type; HUS, hemolytic uremic syndrome; BD, bloody diarrhea.
†Mean unbiased estimate.

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