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Volume 15, Number 9—September 2009

Research

Increasing Incidence of Zygomycosis (Mucormycosis), France, 1997–2006

Dounia Bitar, Dieter Van Cauteren, Fanny Lanternier, Eric Dannaoui, Didier Che, Francoise Dromer, Jean-Claude Desenclos, and Olivier Lortholary
Author affiliations: Institut de Veille Sanitaire, Saint Maurice, France (D. Bitar, D. Van Cauteren, D. Che, J.-C. Desenclos); Université Paris-Descartes, Paris, France (F. Lanternier, O. Lortholary); Institut Pasteur, Paris (E. Dannaoui, F. Dromer, O. Lortholary); Hôpital Georges Pompidou, Paris (E. Dannaoui).

Main Article

Table

Distribution of zygomycosis cases and deaths, by underlying disease, France, 1997–2006

Known risk factors No. cases No. deaths Case-fatality ratio, %*
Bone marrow transplantation
33
12
36.4
Hematologic malignancies 59 21 35.6
Neutropenia/aplastic anemia 23 11 47.8
Acute lymphoid/myeloid leukemias 20 6 30.0
Other lymphoid/myeloid disorders
16
4
25.0
Nonhematologic immunodepression 64 8 12.5
Cancers of the solid organs 28 3 10.7
HIV/AIDS 26 1 3.8
Solid organ transplantations
10
4
40.0
Diabetes
86
8
9.3
No known risk factor
289
12
4.2
Total 531 61 11.5

*Calculated only for the 61 deaths reported in hospital records for which information about underlying diseases was available.

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