Emerging Infectious Disease ISSN: 1080-6059

Cross-reactive Antibodies against Avian Influenza Virus A (H5N1)

Sathit Pichyangkul

, Anan Jongkaewwattana, Arunee Thitithanyanont, Peeraya Ekchariyawat, Suwimon Wiboon-ut, Amporn Limsalakpetch, Kosol Yongvanitchit, Utaiwan Kum-Arb, Rangsini Mahanonda, Pongsak Utaisincharoen, Stitaya Sirisinha, Carl J. Mason, and Mark M. Fukuda

Author affiliations: Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand (S. Pichyangkul, A. Limsalakpetch, K. Yongvanitchit, U. Kum-Arb, C.J. Mason, M.M. Fukuda); National Center of Genetic Engineering and Biotechnology, Bangkok (A. Jongkaewwattana); Mahidol University, Bangkok (A. Thitithanyanont, P. Ekchariyawat, S. Wiboon-ut, P. Utaisincharoen, S. Sirisinha); Chulalongkorn University, Bangkok (R. Mahanonda)

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Figure

Neutralization of avian influenza virus A (H5N1) by intravenous immunoglobulin (IVIg) preparations measured by percentage reduction in plaque number (A) and plaque size (B). Monolayers of MDCK cells were infected with virus and overlaid with agar containing various concentrations of IVIg. After 2 days, plaques were detected by staining with crystal violet. Shown is a sample of viral plaques with agar overlay containing different dilutions (1:50–1:800) of Human Immunoglobulin, pH 4.0, (Harbin Seq

Figure. Neutralization of avian influenza virus A (H5N1) by intravenous immunoglobulin (IVIg) preparations measured by percentage reduction in plaque number (A) and plaque size (B). Monolayers of MDCK cells were infected with virus and overlaid with agar containing various concentrations of IVIg. After 2 days, plaques were detected by staining with crystal violet. Shown is a sample of viral plaques with agar overlay containing different dilutions (1:50–1:800) of Human Immunoglobulin, pH 4.0, (Harbin Sequel Bio-Engineering Pharmaceutical, Harbin, People’s Republic of China) IVIg (C). Data are mean ± SE of 3 experiments.

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