Volume 16, Number 1—January 2010
Dispatch
Enterotoxigenic Escherichia coli Multilocus Sequence Types in Guatemala and Mexico
, John Klena, Claudia Rodas, August Louis Bourgeois, Olga Torres, Ann-Mari Svennerholm, and Åsa SjölingTable
Comparison of ETEC isolates and clinical and demographic information collected during study of US travelers to Guatemala and Mexico and resident children from Guatemala*
| Isolate† | Toxin/CF profile | Geographic origin | Date of collection | Severity of diarrhea‡ | Age/sex | MLST sequence type |
|---|---|---|---|---|---|---|
| Travelers | ||||||
| E617 | STp/CS6 | Antigua, Guatemala | 2000 Jun 19 | Mild | 24 y/M | 182 |
| E830 | STp/CS6 | Traveling in Guatemala | 2002 Sep 23 | Moderate–severe | 30 y/M | 182 |
| E539 | STp/CS6 | Cuernavaca, Mexico | 2000 Jul 13 | Moderate–severe | 36 y/F | 182 |
| E576 | STp/CS6 | Cuernavaca, Mexico | 2000 Jul 15 | Moderate–severe | 50 y/M | 182 |
| E494 | STp/CS6 | Antigua, Guatemala | 1999 Jul 3 | Moderate–severe | 37 y/F | 182 |
| E695 | STp/CS6 | Antigua, Guatemala | 2001 Jan 15 | Moderate–severe | 44 y/M | 182 |
| E396 | STp/CS6 | Antigua, Guatemala | 1998 Jul 30 | Moderate–severe | 49 y/M | 726 |
| E848 | STp/CS6 | Traveling in Guatemala | 2003 Apr 28 | Moderate–severe | 27 y/M | 727 |
| E368 | STp/CS6 | Cuernavaca, Mexico | 1999 Aug 11 | Asymptomatic§ | 30 y/F | 278 |
| E416 | STp/CS6 | Antigua, Guatemala | 1999 May 30 | Moderate–severe | 25 y/M | 278 |
| E521 | STp/CS6 | Cuernavaca, Mexico | 2001 Apr 8 | Moderate–severe | 51 y/F | 278 |
| E837 | STp/CS6 | Traveling in Guatemala | 2002 Sep 23 | Moderate-severe | 30 y/M | 278 |
| E844¶ | STp/CS6 | Traveling in Guatemala | 2003 Apr 28 | Moderate–severe | 29 y/F | 712 |
| E382 | STp/CS6 | Antigua, Guatemala | 1998 Jul 1 | Moderate–severe | 21 y/F | 398 |
| E447 | STp/CS6 | Antigua, Guatemala | 1999 Jun 21 | Moderate–severe | 46 y/F | 398 |
| E670 | STp/CS6 | Antigua, Guatemala | 2000 Jul 17 | Moderate–severe | 27 y/F | 398 |
| E850¶ |
STp/CS6 |
Traveling in Guatemala |
2003 May 8 |
Asymptomatic |
29 y/F |
398 |
| Children | ||||||
| E856 | STp/CS6 | SMJ, Guatemala | 2002 Jun 21 | Persistent moderate–severe | 10 mo/M | 398 |
| E861 | STp/CS6 | SMJ, Guatemala | 2002 Jul 4 | Persistent moderate–severe | 34 mo/M | 398 |
| E870 | STp/CS6 | SMJ, Guatemala | 2002 Jul 26 | Moderate | 11 mo/M | 398 |
| E871 | STp/CS6 | SMJ, Guatemala | 2002 Aug 1 | Moderate | 22 mo/F | 398 |
| E872 | STp/CS6 | SMJ, Guatemala | 2002 Aug 7 | Moderate | 12 mo/F | 398 |
| E879 | STp/CS6 | SMJ, Guatemala | 2002 Aug 23 | Moderate | 26 mo/F | 398 |
| E874 | STh/CS6 | SMJ, Guatemala | 2002 Aug 19 | Moderate | 18 mo/F | 443 |
*ETEC, enterotoxigenic Escherichia coli; CF, colonization factor; MLST, multilocus sequence typing; SMJ, Santa María de Jesús.
†World Health Organization Collaborating Centre for Research on Enterotoxigenic Escherichia coli strain collection number.
‡Classification of diarrheal disease severity in travelers was based on the study case definition of travelers’ diarrhea with an associated gastrointestinal symptom rated as mild, moderate, or severe (5). Moderate symptoms interfered with daily activity, and severe symptoms prevented normal daily activity. Disease classification in children was based on the number of diarrheal stools in a 24-hour period (3/24 h, mild; 4–5/24 h, moderate; >6/24 h, severe). Diarrhea accompanied by vomiting was classified as severe; diarrhea lasting >14 days was classified as persistent.
§Not travelers’ diarrhea.
¶Strains E844 and E850 were isolated from the same person participating in the antimicrobial drug treatment study. Strain E850 was isolated after completion of a course of antimicrobial drugs.
