Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 16, Number 2—February 2010

Dispatch

Severe Leptospirosis in Hospitalized Patients, Guadeloupe

Cécile Herrmann-StorckComments to Author , Magalie Saint Louis, Tania Foucand, Isabelle Lamaury, Jacqueline Deloumeaux, Guy Baranton, Maurice Simonetti, Natacha Sertour, Muriel Nicolas, Jacques Salin, and Muriel Cornet
Author affiliations: Guyane University, Guadeloupe, French West Indies (C. Herrman-Storck, M. Saint Louis, T. Foucand, I. Lamaury, J. Deloumeaux, M. Simonetti, M. Nicholas, J. Salin); Institut Pasteur, Paris, France (G. Baranton, N. Serour, M. Cornet); and Paris Descartes University, Paris (M. Cornet)

Main Article

Table 1

Demographic, epidemiologic, and clinical characteristics as a function of severity among 168 case-patients with confirmed leptospirosis, Hospital of Pointe-à-Pitre, Guadeloupe, French West Indies, 2003–2004*

Characteristics
Univariate analysis†

Multivariate analysis
All case-patients, 
N = 168
Case-patients with severe disease, n = 24
Case-patients 
with nonsevere disease, n = 144
p value
OR (95% CI)
p value
Male sex 143/168 (85.1) 18/24 (75) 125/144 (86.8) 0.2 2.6 (0.4–17.7) 0.3
Age, y, mean ± SD (no. patients)
F 58.5 ± 17.9 (25) 55.5 ± 2.4 (6) 36.7 ± 8 (19) 0.05
M
47 ± 15.9 (143)
51.8 ± 6.5 (18)
49.6 ± 2.9 (125)
0.5



Exposure to occupational risk‡ 74/133 (55.6) 12/20 (60) 62 /113 (54.8) 0.6
Contact with swine 41/115 (35.6) 5/10 (50) 36/105 (34.2) 0.5
Contact with cattle 36/113 (31.9) 1/10 (10) 35/103 (34) 0.8
Contact with rodents
56/114 (49.1)
3/9 (33.3)
53/105 (50.5)
0.5



Medical history
Duration of illness before 
 antibacterial therapy§ >10 d 21/141 (14.9) 7/22 (31.8) 14/119 (11.8) 0.01 4.8 (1.1–20.2) 0.032
Diabetes mellitus 13/75 (17.3) 3/22 (13.6) 10/53 (18.9) 0.5
Chronic hypertension ¶ 24/75 (32) 9/22 (40.9) 15/53 (28.3) 0.2 30.9 (6.0–157.4) <0.001
Chronic alcoholism#
29/75 (38.7)
11/22 (50.0)
18/53 (34)
0.2

16.8 (4.1–57.9)
<0.001
Initial features
Hypothermia (<36.5°C) 28/144 (19.4) 7/23 (30.4) 21/121 (17.3) 0.1 4.6 (0.9–24.6) 0.07
Hyperthermia (>37.7°C) 82/144 (56.9) 10/23 (43.5) 72/121 (59.5) 0.1 3.8 (0.7–21.2) 0.12
Hypotension, SBP <100 mm Hg 24/143 (16.8) 7/20 (35) 17/123 (13.8) 0.02 0.3 (0.1–1.8) 0.2
Myalgia 73/77 (94.8) 12/13 (92.3) 61/64 (95.3) 0.6
Consciousness disorders 10/119 (8.4) 4/13 (30.8) 6/106 (5.7) 0.01 3.8 (1.1–13.2) 0.035
Nuchal rigidity 10/116 (8.6) 2/12 (16.7) 8/104 (7.7) 0.2
Headache 70/91 (76.9) 5/7 (71.4) 65/84 (77.4) 0.7
Conjunctival suffusion 46/116 (39.6) 4/12 (33.3) 42/104 (40.4) 0.4
Icterus 57/117 (48.7) 9/12 (75) 48/105 (45.7) 0.1 5.9 (1.1–31.1) 0.036
Hemorrhage** 15/165 (9.1) 5/24 (20.8) 10/141 (7.1) 0.04 4.2 (0.3–67.9) 0.31
Hepatosplenomegaly 30/86 (34.9) 7/11 (63.6) 23/75 (30.7) 0.02 1.7 (0.2–13.9) 0.62
Abdominal pain 64/124 (51.6) 14/18 (77.8) 50/106 (47.2) 0.009 3 (0.7–13.2) 0.139
Digestive disorders (diarrhea, 
 vomiting) 66/105 (62.8) 12/15 (80) 54/90 (60) 0.2 3.5 (0.7–18.0) 0.12
Abnormalities at chest 
 auscultation†† 19/135 (14.1) 8/17 (47) 11/118 (9.3) <0.001 8.7 (1.8–41.3) 0.006
Chest radiologic anomalies‡‡ 22/112 (19.6) 6/16 (37.5) 16/96 (16.7) 0.05 0.8 (0.1–10.4) 0.85
Alveolar infiltrate 9/112 (8.0) 5/16 (31.2) 4/96 (4.2) <0.001
Electrocardiographic disorders§§ 22/73 (30.1) 5/16 (31.2) 17/57 (29.8) 0.9
Oliguria¶¶ or anuria 34/128 (26.6) 10/23 (43.5) 24/105 (22.9) 0.04 5.6 (1.5–20.6) 0.009

*OR, odds ratio; CI, confidence interval; SBP, systolic blood pressure. Boldface indicates significance.
†All values no. case-patients/no. examined (%) except as indicated.
‡Farming, livestock farming, construction, and gardening.
§Ampicillin or cefotaxime.
¶As reported by patients with specific therapy.
#Defined as alcohol dependence.
**Hemoptysis, hematuria, purpura, bleeding of the gums, and hematemesis.
††Crackles or ronchi.
‡‡Only anomalies of the lungs.
§§Excluding patients >60 y of age or with sinus tachycardia.
¶¶Urinary volume <400 mL/d.

Main Article

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO