Volume 16, Number 2—February 2010
Perspective
Effects of Coronavirus Infections in Children
Nicola Principi
, Samantha Bosis, and Susanna Esposito
, Samantha Bosis, and Susanna EspositoTable
Main studies of the epidemiology and clinical relevance of HCoV-HKU1 in infants and children*
| Study | Location and period | Population | No. samples tested | No. (%) patients with positive test results | Comments |
|---|---|---|---|---|---|
| Lau et al. (20) | Hong Kong; 2004 Apr–2005 Mar | 629 children with RTIs, 6 mo–5 y; inpatients | 629 | 10 (1.6) | 11 patients with URTIs, 1 with pneumonia, 1 with bronchiolitis, 5 with febrile seizures; 3 with underlying disease |
| Vabret et al. (24) | Canada; 2005 Feb–Mar | 83 children with RTIs, <5 y; negative for RSV, influenza A/B, PIV 1–3, adenovirus; inpatients | 83 | 5 (6.0) | 3 patients with gastroenteritis, 1 with febrile seizures; mean age 26 mo |
| Sloots et al. (25) | Australia; 2004 May–Aug | 259 children with RTIs, <5 y; inpatients and outpatients | 259 | 10 (3.8) | 1 patient with co-infection |
| Talbot et al. (34) | USA; 2001 Oct–2003 Sep | 1,055 children with RTIs, <5 y; inpatients | 1,055 | 4 (0.4) | Mild episodes |
*HCoV, human coronavirus; RTI, respiratory tract infection; URTI, upper respiratory tract infection; RSV, respiratory syncytial virus; PIV, parainfluenza virus.
