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Volume 16, Number 2—February 2010

Dispatch

Coccidioidomycosis among Scholarship Athletes and Other College Students, Arizona, USA1

Nicole G. Stern and John N. GalgianiComments to Author 
Author affiliations: University of Arizona Campus Health Service, Tucson, Arizona, USA (N.G. Stern); University of Arizona College of Medicine, Tucson (J.N. Galgiani)

Suggested citation for this article

Abstract

To compare coccidioidomycosis case rates among groups of young adults in a disease-endemic region, we reviewed medical charts for serologic testing and coding. Case rates were higher for scholarship athletes than for other students and paralleled 5× more serologic testing. Our findings underscore the need to routinely test patients for coccidioidomycosis.

Coccidioidomycosis, known commonly as valley fever, is a fungal infection endemic to the southwestern United States (1). The illness most commonly caused is community-acquired pneumonia (2,3). Some researchers estimate that ≈50,000 infections are severe enough to warrant medical attention (1,4); however, reported infections represent less than a quarter of this estimate, creating uncertainty about the true impact of valley fever.

Scholarship athletes receive financial support for their educations in return for participation in intercollegiate varsity competition. Athletes comprise a precisely defined group and afford a special opportunity to calculate endemic risk for infection within a young adult population. We calculated case rates for scholarship athletes and then compared the rates with those for other students and persons of college age.

The Study

The Campus Health Service at the University of Arizona is located on campus in Pima County. The average yearly enrollment during 1998–2006 of 36,000 was used for calculating case rates for all students (5). Scholarship athletes at the university total 475 annually.

Campus Health medical charts for January 1, 1998, through December 31, 2006, were reviewed for serologic testing for coccidioidomycosis. Charts were also reviewed for International Classification of Diseases, 9th edition (ICD-9), codes for coccidioidomycosis (114.0–114.5, 114.9) to identify students in whom the diagnosis was made by testing elsewhere. Athletes’ charts were identified based on billing information.

Most serologic testing, identified by its current procedural terminology (CPT) code, was performed by the Campus Health laboratory, which used PREMIER Coccidioides enzyme immunoassay (Meridian Diagnostics, Cincinnati OH, USA). Occasionally, ≈10% of the time, serum samples were tested by a single commercial laboratory, which used immunodiffusion testing for precipitin-type or complement fixing–type antibodies (6). Any positive result was considered diagnostic. Students tested multiple times for coccidioidomycosis were counted once, either in the first year for which results were positive or in the year first tested if all results were negative. Individual charts were reviewed for those students who did not have coccidioidal testing done at Campus Health and were included only if the diagnosis could be corroborated by outside laboratory documentation. A case of coccidioidomycosis was defined as one in which the diagnosis could be corroborated by positive coccidioidal serologic results, fungal culture, or histologic identification of spherules in biopsy specimens.

In addition, charts of all athletes who had coccidioidal infection were reviewed for demographic information, type of sport (indoors vs. outdoors), and extent of disease. Arizona state statistics were provided by the Arizona Department of Health Services. Not all statistics for all age ranges were available. All data were analyzed by using SPSS 11.0 for Windows (SPSS Inc, Chicago, IL, USA). Significance tests used the Fisher exact χ2. This study was approved by the University of Arizona Institutional Review Board and by the Campus Health Service Departmental Review Committee.

Of 2,754 student medical charts selected for review based on routine serologic testing for coccidioidomycosis or an ICD-9 code for coccidioidomycosis, 305 students were found to have coccidioidomycosis. Of these 305, a total of 297 had positive coccidioidomycosis results by serologic testing done at Campus Health and 8 were identified with diagnostic results from other laboratories. The resulting annual student case rate for all students was 94.1/100,000.

Annual rates for college students are 3–4× higher than available county and state rates for various age ranges (Table). The average age range of university students is 17–23 years. Because Pima County statistics includes cases reported to the state by Campus Health, actual differences between student rates and nonstudent Pima County rates for persons of similar ages would be even greater than represented here.

Coccidioidal infections occurred in 16 scholarship athletes. The composite case rate, or annual incidence of coccidioidomycosis, was 374/100,000 (95% confidence interval [CI] 192–639) for scholarship athletes compared with 90/100,000 (95% CI 79–103) for other students (p<0.00001). In parallel, a much greater proportion (4.6%, 95% CI 3.9–5.4) of scholarship athletes were tested for coccidioidal antibodies than were other students (0.8%, 95% CI 0.77–0.84%) (p<0.000001). Infection for all but 1 athlete with disseminated infection was limited to the chest and/or skin, which resolved either untreated or after several months of antifungal therapy. The age distribution of scholarship athletes was the same as for other students, and only 1 of 16 athletes was from Arizona. Female athletes with coccidioidal infections comprised 56% of the total compared with 41% of all uninfected athletes (p = 0.31). For 81% of infected athletes, sports competition took place outdoors, whereas 88% of uninfected athletes competed outdoors (p = 0.43).

Conclusions

A recent study in Arizona found that <13% of patients with community acquired pneumonia were tested for coccidioidomycosis (7). In contrast, Campus Health Service at the University of Arizona tested ≈50% of students with community acquired pneumonia for coccidioidomycosis (8,9). Consequently, proportionately higher than age-adjusted Pima County case rates are found. Similarly, the case rate of 374/100,000 for scholarship athletes, >4× higher than that for other students, is associated with a >5-fold increase in coccidioidal testing. Therefore, it would seem that most, if not all, of the increased case-rate for athletes can be accounted for by increased testing; little, if any, increased susceptibility can be attributed to increased exercise or athletic training. We did not evaluate why clinicians tested more scholarship athletes. We speculate that etiologic diagnoses for any illness that reduced physical performance were sought more frequently for scholarship athletes than for other students. However, we cannot entirely exclude the possibility that the higher rate of testing was to some extent a consequence of higher rates of pneumonia in scholarship athletes. In any instance, it would appear that more complete testing for community acquired pneumonia associated with valley fever does result in considerably higher estimates of case rates for this fungal infection.

In the past, skin test conversion rates have suggested an annual infection rate of ≈3,000/100,000 (10). A 2007 telephone survey conducted by the Arizona Department of Health Services of persons reported with new diagnoses of coccidioidomycosis found that the median length of residence in an endemic area was 17 years (11), further suggesting an average annual infection rate of ≈3%. In this context, rates for scholarship athletes fall well within these other estimates.

Case rates among scholarship athletes were actually underrepresented in outdoor sports, and the spectrum of disease severity was in line with that found in past studies of the student population as a whole (8). Many scholarship athletes come from regions where coccidioidomycosis is not endemic. Because fewer of these students had prior coccidioidal infection, the annual risk for the group as a whole would be slightly increased as shown in a previous report from the same college health group (9). Arizona state statistics show a marked increase with age in case rates, e.g., 163 cases/100,000 for persons >65 years of age. Our findings do not discount the possibility that immune responses of elderly patients differs from those of younger patients; disease in the elderly is more severe (12). However, our study suggests that at least an equal proportion of young adults have clinical illness from coccidioidal infection sufficient to seek medical evaluation.

Our findings address infection among college students, particularly scholarship athletes, and support a recommendation that student health clinicians and team physicians consider coccidioidomycosis as a possible etiology of illness in students who live in or have traveled recently to disease-endemic regions. More generally, our findings reinforce practice guidelines revised by the Infectious Diseases Society of America for management of community-acquired pneumonia to assist clinicians in evaluating patients with endemic exposure (13).

Dr Stern is a specialist in internal medicine and sports medicine in Tucson, Arizona. Her research interest is infections in sports medicine.

Dr Galgiani is a faculty member at the University of Arizona College of Medicine trained in internal medicine and infectious diseases. His research interest is medical mycology, in particular, coccidioidomycosis.

Acknowledgment

We are most grateful to Jeff Alquist and Kim Kreitner for their assistance with the manuscript and for obtaining electronic medical records. We also thank Shoana Anderson and Clarisse Tsang for providing state and Pima County statistics, as well as Carol DePillo for providing results of serologic testing.

References

  1. Galgiani JN, Ampel NM, Blair JE, Catanzaro A, Johnson RH, Stevens DA, Coccidioidomycosis. Clin Infect Dis. 2005;41:121723. DOIPubMed
  2. Valdivia L, Nix D, Wright M, Lindberg E, Fagan T, Lieberman D, Coccidioidomycosis as a common cause of community-acquired pneumonia. Emerg Infect Dis. 2006;12:95862.PubMed
  3. Kim MM, Blair JE, Carey EJ, Wu Q, Smilack JD. Coccidioidal pneumonia, Phoenix, Arizona, USA, 2000–2004. Emerg Infect Dis. 2009;15:397401. DOIPubMed
  4. The University of Arizona Valley Fever Center for Excellence. Valley fever in humans. Who gets it? [cited 2009 April 27]. http://www.vfce.arizona.edu
  5. The University of Arizona Office of Institutional Research and Evaluation fact book 2007–2008. Headcount enrollment. Academic years 1998 to 2007. 2009 [cited 2009 Feb 28]. http://oirps.arizona.edu/files/Fact_Book/NC_Factbook07-08.pdf
  6. Wieden MA, Lundergan LL, Blum J, Delgado KL, Coolbaugh R, Howard R, Detection of coccidioidal antibodies by 33-kDa spherule antigen, coccidioides EIA, and standard serologic tests in sera from patients evaluated for coccidioidomycosis. J Infect Dis. 1996;173:12737.PubMed
  7. Chang DC, Anderson S, Wannemuehler K, Engelthaler DM, Erhart L, Sunenshine RH, Testing for coccidioidomycosis among patients with community-acquired pneumonia. Emerg Infect Dis. 2008;14:10539. DOIPubMed
  8. Kerrick SS, Lundergan LL, Galgiani JN. Coccidioidomycosis at a university health service. Am Rev Respir Dis. 1985;131:1002.PubMed
  9. Yozwiak ML, Lundergan LL, Kerrick SS, Galgiani JN. Symptoms and routine laboratory abnormalities associated with coccidioidomycosis. West J Med. 1988;149:41921.PubMed
  10. Dodge RR, Lebowitz MD, Barbee RA, Burrows B. Estimates of C. immitis infection by skin test reactivity in an endemic community. Am J Public Health. 1985;75:8635. DOIPubMed
  11. Arizona Department of Health Services. Valley fever annual report; 2007 [cited 2009 Apr 13]. http://www.azdhs.gov/phs/oids/epi/pdf/VF_Annual_Report_2007.pdf
  12. Blair JE, Mayer AP, Currier J, Files JA, Wu Q. Coccidioidomycosis in elderly persons. Clin Infect Dis. 2008;47:15138. DOIPubMed
  13. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44:S2772. DOIPubMed

Table

Suggested citation for this article: Stern NG, Galgiani JN. Coccidioidomycosis among scholarship athletes and other college students, Arizona, USA. Emerg Infect Dis [serial on the Internet]. 2010 Feb [date cited]. Available from http://wwwnc.cdc.gov/eid/article/16/2/09-0918.htm

DOI: 10.3201/eid1602.090918

1Data were presented at the Valley Fever Center for Excellence/Arizona College of Public Health Jointly Sponsored Mini Symposium, Arizona Cancer Center, Tucson, Arizona, November 12, 2008.

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Table of Contents – Volume 16, Number 2—February 2010

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John N. Galgiani, Valley Fever Center for Excellence, University of Arizona College of Medicine, PO Box 245215, Tucson, AZ 85724, USA





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