Volume 16, Number 4—April 2010
Novel Corynebacterium diphtheriae in Domestic Cats
|Strain||Culture collection||Source||Diphtheria toxin||GenBank accession no.
|16S rRNA||rpoB||tox gene|
|CD443||ATCC BAA-1774||Cat 1, right ear||Nontoxigenic||FJ409572||FJ415317||FJ376656|
|CD448||ND||Cat 1, right ear||Nontoxigenic||FJ409573||ND||FJ422272|
|CD449||ND||Cat 1, left ear||Nontoxigenic||FJ409574||ND||FJ422273|
|CD450||ND||Cat 2, left ear||Nontoxigenic||FJ409575||FJ415318||FJ422274|
|C. diphtheriae biotype mitis||NCTC 10356†||Human nose||Nontoxigenic||GQ118340||GQ409648||ND|
|C. diphtheriae biotype gravis||NCTC 10648||Unknown||Toxigenic||ND||ND||ND|
|C. diphtheriae biotype gravis||NCTC 11397T ATCC 27010T||Unknown||Nontoxigenic||GQ118341||GQ409649||ND|
|C. diphtheriae biotype gravis||NCTC 13129 ATCC 700971||Human throat||Unknown||GQ118344||GQ409650||ND|
|C. pseudotuberculosis||NCTC 3450T||Sheep gland||Unknown||GQ118342||GQ409651||ND|
|C. ulcerans||NCTC 12077||Human throat||Unknown||GQ118343||ND||ND|
|C. ulcerans||NCTC 7910||Human throat||Unknown||GQ118345||ND||ND|
*CD, Centers for Disease Control and Prevention identifier number; ATCC, American Type Culture Collection; ND, not deposited in this study; NCTC, National Collection of Type Cultures, London, UK. Additional strains used as controls for specific assays: toxigenic C. diphtheriae biotype belfanti isolates used for real-time PCR of tox gene were 718, G4182, C59, C60, C75, C76, C77; toxigenic C. diphtheriae ATCC 27012 used as positive control for Elek; C. diphtheriae NCTC 10481 and C. ulcerans CD199 used as positive and negative controls for Vero cell assay.
†NCTC 10356 is described in the NCTC catalogue as C. diphtheriae biotype mitis; however, analyses in this study found this strain to be nitrate negative and therefore consistent with C. diphtheriae biotype belfanti. Thus, it was used in this study as a belfanti reference strain.
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