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Volume 16, Number 4—April 2010

Research

Phylogenetic Analysis of Enterohemorrhagic Escherichia coli O157, Germany, 1987–2008

Christian Jenke, Dag Harmsen, Thomas Weniger, Jörg Rothgänger, Eija Hyytiä-Trees, Martina Bielaszewska, Helge Karch, and Alexander MellmannComments to Author 
Author affiliations: Institute for Hygiene, Münster, Germany (C. Jenke, M. Bielaszewska, H. Karch, A. Mellmann); Department of Periodontology, Münster (D. Harmsen, T. Weniger); Ridom GmbH, Würzburg, Germany (J. Rothgänger); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E. Hyytiä-Trees)

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Table 2

MLVA cluster profile of enterohemorrhagic Escherichia coli O157, Germany, 1987–2008*

MLVA cluster Cluster-defining MLVA profile No. strains 
(% sorbitol-fermenting) No. MLVA profiles Years of strain isolation
1 4/8/-2/2/3/9/-2/5 61 (100) 16 1988, 1989, 1993, 1995–2008
2 7/7/13/4/5/7/-2/7 11 (0) 7 1996–1998, 2000, 2002, 2005, 2006
3 11/8/10/3/5/6/8/3 9 (0) 8 2001, 2004, 2005, 2007, 2008
4 18/7/8/3/5/7/-2/7 8 (0) 8 1996–1999, 2001, 2005, 2006
5 5/7/13/5/6/6/6/6 7 (0) 5 1991, 1999, 2007
6 12/7/16/3/5/6/5/7 5 (0) 5 1990, 1992, 1999, 2001, 2004
7 18/7/10/4/4/9/4/9 5 (0) 4 1996, 1998, 2001–2003
8 9/7/9/4/6/7/9/8 3 (0) 3 2007, 2008
9 13/7/11/4/4/8/4/8 3 (0) 3 1992, 1993, 2002
10 6/6/16/3/6/6/6/6 3 (0) 3 2005, 2006
11 11/9/10/5/7/6/11/7 3 (0) 3 1996, 2000, 2007
12 8/10/13/6/7/7/5/6 3 (0) 2 2002
13 9/7/13/3/6/6/10/7 3 (0) 2 1997, 2002
14 NA 2 (0) 2 2000
15 NA 2 (0) 2 1998, 2000
16 NA 2 (0) 2 1991
17 NA 2 (0) 2 1995, 1997
18 NA 2 (0) 2 1998, 2000
19 NA 2 (0) 2 2001, 2003
Singletons 66 (0) 60 All years except 1990, 1995, and 2004

*MLVA, multilocus variable number tandem repeat analysis; NA, not applicable because cluster comprises <3 strains. Singletons, MLVA profiles that are not included in a certain cluster. MLVA profiles are defined by repeat numbers after the following variable number tandem repeat (VNTR) locus order: 3/34/9/25/17/19/36/37 with EDL933 as standard with the following MLVA profile: 9/10/11/5/6/6/8/7 (based on genome sequence analysis). Strains belonged to 1 cluster if they differed at <2 VNTR loci.

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