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Volume 17, Number 10—October 2011

Dispatch

Novel Arenavirus, Zambia

Akihiro IshiiComments to Author , Yuka Thomas, Ladslav Moonga, Ichiro Nakamura, Aiko Ohnuma, Bernard Hang’ombe, Ayato Takada, Aaron Mweene, and Hirofumi Sawa
Author affiliations: Hokkaido University, Sapporo, Japan (A. Ishii, Y. Thomas, I. Nakamura, A. Ohnuma, A. Takada, H. Sawa); University of Zambia, Lusaka, Zambia (A. Ishii, Y. Thomas, L. Moonga, I. Nakamura, B. Hang’ombe, A. Takada, A. Mweene, H. Sawa)

Main Article

Table 2

Functional motifs in the Z and glycoprotein precursor proteins of Old World arenaviruses*

Strain Late domains† Strain S1P cleavage site‡
LUNV (Lusaka) PTAPKESASNPPPYSP LUNV (Lusaka) RRLM-GTFTW
LUNV (Namwala) PTAPKEPARNPPPYSP LUNV (Namwala) RRLM-GTFTW
MOBV PTAPPPEATNPPPYSP MOBV RRLM-GTFTW
MOPV PTAPPEIPPSQNPPPYSP IPPYV RRLM-STFTW
MORV PTAPPEAMPSQQPPPYQP LUJV RKLM-KLFQW
LASV PTAPPTGAADSIRPPPYSP MOPV RRLL-GLFTW
IPPYV PSAPPSPSPPPYSP MORV RRLL-GLFTW
LCMV STAPSSPPPYEE§ LASV RRLL-GTFTW
DANV STAPSSPPPYEE LCMV RRLA-GTFTW
LUJV PSAPPL DANV RRLA-GTFTW

*S1P, cellular proprotein convertase site 1 protease; LUNV, Luna virus; -, S1P cleavage site; MOBV, Mobala virus; MOPV, Mopeia virus; MORV, Morogoro virus; LASV, Lassa virus; IPPYV, Ippy virus; LCMV, lymphocytic choriomeningitis virus; DANV, Dandenong virus; LUJV, Lujo virus.
†Conserved P(T/S)AP and PPPY motifs in the Z protein are in boldface.
‡R(R/K)LM is considered a putative, although unconfirmed, S1P cleavage site.
§STAP is considered a putative, although unconfirmed, PTAP motif.

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