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Volume 17, Number 11—November 2011

Dispatch

International Spread of MDR TB from Tugela Ferry, South Africa

Graham S. CookeComments to Author , R. Kate Beaton, Richard J. Lessells, Laurence John, Simon Ashworth, Onn Min Kon, O. Martin Williams, P. Supply, P. Moodley, and Alexander S. Pym
Author affiliations: Imperial College, London, UK (G.S. Cooke); University of KwaZulu-Natal, Mtubatuba, South Africa (G.S. Cooke, R.J. Lessells); National Mycobacterium Reference Laboratory, London (R.K. Beaton); Imperial College National Health Service Healthcare Trust, London (L. John, S. Ashworth, O.M. Kon); Health Protection Agency Regional Laboratory Services, Bristol, UK (O.M. Williams); University of Lille–Nord de France, Lille, France (P. Supply); University of KwaZulu-Natal, Durban, South Africa (P. Moodley); Medical Research Council, Durban (A.S. Pym)

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Table

Locus typing for tuberculosis patient isolate according to standard nomenclature based on chromosomal locations*

Genotypic family and strain or isolate
Allele at MIRU-VNTR locus
154
577
580
802
960
1644
2059
2165
2461
2531
2687
2996
3007
3192
4348
F15/LAM4/KZN
Patient isolate 1 4 3 4 4 3 2 2 2 6 1 5 3 3 2
605 (reference) 1 4 2 4 4 3 2 2 2 6 1 5 3 3 2
1435 1 4 2 5 4 3 2 2 2 6 1 5 3 3 2
R506 1 4 2 3 3 3 2 2 2 6 1 4 3 3 2
V2475 1 4 2 3 3 3 2 2 2 6 1 4 3 3 2
4207 1 4 2 3+4 3+4 3 2 2 2 6 1 4+5 3 3 2
F11/LAM
F11 2 4 2 3 3 3 2 2 2 6 1 4 3 3 2

*Patient’s isolate most closely matches F15/LAM4/KZN605 reference strain by a single locus variation, a genetic distance equal to or lower than that separating other known F15/LAM4/KZN strains (i.e., 1–3 locus variations). MIRU-VNTR, mycobacterial interspersed repetitive units–variable number tandem repeats.

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