Volume 17, Number 11—November 2011
THEME ISSUE CHOLERA IN HAITI
Drug-Resistance Mechanisms in Vibrio cholerae O1 Outbreak Strain, Haiti, 2010
Maria Sjölund-Karlsson , Aleisha Reimer, Jason P. Folster, Matthew Walker, Georges Dahourou, Dhwani Govil Batra, Irene Martin, Kevin Joyce, Michele B. Parsons, Jacques Boncy, Jean M. Whichard, and Matthew W. Gilmour
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M. Sjölund-Karlsson, D.G. Batra, K. Joyce, M.B. Parsons, J.M. Whichard); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A. Reimer, M. Walker, I. Martin, M.W. Gilmour); IHRC Inc., Atlanta (J.P. Folster); Centers for Disease Control and Prevention, Port-au-Prince, Haiti (G.A. Dahourou); Ministry of Public Health and Population, Port-au-Prince (J. Boncy)
Figure 1. Genetic organization of the 2010 Haiti Vibrio cholerae O1 integrating conjugative element (ICE), ICEVchHai1. The ICE contained 97,915 bp and 95 open reading frames. Coding sequences were identified and manually annotated by using an in-house modified version of GenDBv2.2 (Center for Biotechnology at Bielefeld University, Bielefeld, Germany, www.cebitec.uni-bielefeld.de/groups/brf/software/gendb_info/index.html). Regions conserved among previously sequenced ICEs are indicated in black, regions of variability in purple, and previously identified hotspots of homologous recombination in pink. Conserved genes involved in conjugation are indicated in orange. Genes associated with antimicrobial drug resistance (floR [chloramphenicol], strAB [streptomycin], sul2 [sulfamethoxazole], and dfrA1 [trimethoprim]) are indicated in red. The complete sequence of ICEVchHai1 has been deposited into GenBank under accession no. JN648379.
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.