Volume 17, Number 11—November 2011
Dispatch
Influenza B Viruses with Mutation in the Neuraminidase Active Site, North Carolina, USA, 2010–11
Katrina Sleeman, Tiffany G. Sheu, Zack Moore, Susan Kilpatrick, Shikha Garg, Alicia M. Fry, and Larisa V. Gubareva
Table 2
Percentage composition of isoleucine and valine at position 221 in the neuraminidase of virus isolates and clinical specimens with reduced susceptibility to oseltamivir and peramivir, North Carolina, USA, 2010−11 influenza season*
| Strain designation | Date of collection |
Clinical specimen
|
Virus isolate
| |||
|---|---|---|---|---|---|---|
| % Isoleucine | % Valine | % Isoleucine | % Valine | |||
| B/North Carolina/02/2010 | 2010 Nov 10 | NA | NA | 20 | 80 | |
| B/North Carolina/11/2010 | 2010 No 29 | 5 | 95 | 38 | 62 | |
| B/North Carolina/06/2010 | 2010 Dec 6 | NA | NA | 15 | 85 | |
| B/North Carolina/07/2010 | 2010 Dec 6 | NA | NA | 19 | 81 | |
| B/North Carolina/08/2010 | 2010 Dec 7 | NA | NA | 24 | 76 | |
| B/North Carolina/10/2010 | 2010 Dec 17 | 8 | 92 | 13 | 87 | |
| B/North Carolina/12/2010 | 2010 Dec 20 | 9 | 91 | 15 | 85 | |
| B/North Carolina/13/2010 | 2010 Dec 21 | 10 | 90 | 17 | 83 | |
| B/North Carolina/03/2011 | 2011 Jan 5 | 38 | 62 | 36 | 64 | |
| B/North Carolina/06/2011 | 2011 Jan 24 | 7 | 93 | 15 | 85 | |
| B/North Carolina/01/2011 | 2011 Feb 1 | 11 | 89 | 13 | 87 | |
| B/North Carolina/02/2011 | 2011 Feb 1 | 8 | 92 | 14 | 86 | |
| B/North Carolina/07/2011 | 2011 Jan 31 | 8 | 92 | 15 | 85 | |
| B/North Carolina/08/2011 | 2011 Feb 10 | F | F | 12 | 88 | |
| B/Memphis/20/1996 | NA | NA | NA | 100 |
0
*NA, not available; F, failed in pyrosequencing analysis. 10% is the standard cutoff value for the presence of a single-nucleotide polymorphism because of limitations of the pyrosequencing assay. | |
*NA, not available; F, failed in pyrosequencing analysis. 10% is the standard cutoff value for the presence of a single-nucleotide polymorphism because of limitations of the pyrosequencing assay.
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