Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 17, Number 2—February 2011


Hepatitis E Virus and Neurologic Disorders

Nassim KamarComments to Author , Richard P. Bendall, Jean Marie Peron, Pascal Cintas, Laurent Prudhomme, Jean Michel Mansuy, Lionel Rostaing, Frances Keane, Samreen Ijaz, Jacques Izopet, and Harry R. Dalton
Author affiliations: Author affiliations: Centre Hospitalier Universitaire Rangueil, Toulouse, France (N. Kamar, P. Cintas, L. Rostaing); Université Paul Sabatier, Toulouse (N. Kamar, J.M. Peron, L. Rostaing, J. Izopet); Royal Cornwall Hospital Trust, Truro, UK (R.P. Bendall, F. Keane, H.R. Dalton); Centre Hospitalier Universitaire Purpan, Toulouse (J.M. Peron, J.M. Mansuy, J. Izopet); Centre Hospitalier de Castres, Castres, France (L. Prudhomme); Health Protection Agency, London, UK (S. Ijaz); Peninsula College of Medicine and Dentistry, Truro (H.R. Dalton)

Main Article

Table 2

Clinical presentation for 7 patients with HEV–associated neurologic disorders, Cornwall, UK, and Toulouse, France*

Patient no. Neurologic signs and symptoms Therapy Outcome
1 Acute inflammatory polyradiculoneuropathy Complete resolution
2 Bilateral brachial neuritis Resolution with residual weakness
3 Guillain-Barré syndrome IV Ig Resolution at HEV clearance
4 Ataxia, severe proximal weakness of lower limbs, urine retention, and cognitive dysfunction IS modification Resolution with residual motor deficit
5 Encephalitis IS cessation, foscavir, IV Ig Complete resolution
6 Peripheral demyelinating polyradiculoneuropathy IS modification, IV Ig No improvement
7 Painful sensory peripheral neuropathy Peg-IFN/ribavirin Complete resolution

*HEV, hepatitis E virus; –, no specific therapy; IV Ig, intravenous immunoglobulins; IS, immunosuppressant, Peg-IFN, pegylated interferon.

Main Article

Top of Page The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO