Volume 17, Number 2—February 2011
CME ACTIVITY
Hepatitis E Virus and Neurologic Disorders
Nassim Kamar
, Richard P. Bendall, Jean Marie Peron, Pascal Cintas, Laurent Prudhomme, Jean Michel Mansuy, Lionel Rostaing, Frances Keane, Samreen Ijaz, Jacques Izopet, and Harry R. Dalton
, Richard P. Bendall, Jean Marie Peron, Pascal Cintas, Laurent Prudhomme, Jean Michel Mansuy, Lionel Rostaing, Frances Keane, Samreen Ijaz, Jacques Izopet, and Harry R. DaltonTable 2
Clinical presentation for 7 patients with HEV–associated neurologic disorders, Cornwall, UK, and Toulouse, France*
| Patient no. | Neurologic signs and symptoms | Therapy | Outcome |
|---|---|---|---|
| 1 | Acute inflammatory polyradiculoneuropathy | – | Complete resolution |
| 2 | Bilateral brachial neuritis | – | Resolution with residual weakness |
| 3 | Guillain-Barré syndrome | IV Ig | Resolution at HEV clearance |
| 4 | Ataxia, severe proximal weakness of lower limbs, urine retention, and cognitive dysfunction | IS modification | Resolution with residual motor deficit |
| 5 | Encephalitis | IS cessation, foscavir, IV Ig | Complete resolution |
| 6 | Peripheral demyelinating polyradiculoneuropathy | IS modification, IV Ig | No improvement |
| 7 | Painful sensory peripheral neuropathy | Peg-IFN/ribavirin | Complete resolution |
*HEV, hepatitis E virus; –, no specific therapy; IV Ig, intravenous immunoglobulins; IS, immunosuppressant, Peg-IFN, pegylated interferon.
