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Volume 17, Number 3—March 2011

Letter

Fluoroquinolone-Resistant Mycobacterium tuberculosis, Pakistan, 2005–2009

Kauser JabeenComments to Author , Sadia Shakoor, Shazia Chishti, Afsheen Ayaz, and Rumina Hasan
Author affiliations: Author affiliation: Aga Khan University Hospital, Karachi, Pakistan

Main Article

Table

Resistance patterns and fluoroquinolone resistance rates of Mycobacterium tuberculosis isolates from the Aga Khan University Hospital laboratory, Karachi, Pakistan, 2005–2009*

Year and isolates
Sensitive†
Multidrug resistant
Extensively drug resistant
Other resistance patterns‡
Total
2005
Total 773 643 5 361 1,782
Fluoroquinolone resistant
NT
112 (17.41)
5 (100)
6 (1.66)
NA
2006
Total 949 728 11 195 1,883
Fluoroquinolone resistant
NT
128 (17.58)
11 (100)
7 (3.58)
NA
2007
Total 1,054 782 17 158 2,011
Fluoroquinolone resistant
NT
163 (20.84)
17 (100)
8 (5.06)
NA
2008
Total 1,305 991 32 256 2,584
Fluoroquinolone resistant
NT
351 (35.41)
32 (100)
17 (6.64)
NA
2009
Total 1,560 1,181 53 209 3,003
Fluoroquinolone resistant
48 (3.07)
507 (42.92)
53 (100)
23 (11)
631 (21.01)
p value§
NA
<0.001
NA
<0.001
NA
Total 5,641 4,325 118 1,179 11,263

*Values are no. (%) isolates in that category, except p values. NT, not tested; NA, not applicable.
†To isoniazid, rifampin, pyrazinamide, and ethambutol.
‡Other resistance patterns include isoniazid-monoresistant and polydrug-resistant isolates.
§χ2 trend analysis.

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