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Volume 17, Number 5—May 2011

Letter

Quinine-Resistant Malaria in Traveler Returning from French Guiana, 2010

Lionel Bertaux, Philippe Kraemer, Nicolas Taudon, Aurélie Trignol, Maryse Martelloni, Redouan Saidi, Daniel Parzy, Bruno PradinesComments to Author , and Fabrice Simon
Author affiliations: Author affiliations: Institut de Recherche Biomédicale des Armées, Marseille, France (L. Bertaux, N. Taudon, M. Martelloni, D. Parzy, B. Pradines); Laveran Military Teaching Hospital, Marseille (P. Kraemer, A. Trignol, R. Saidi, F. Simon)

Main Article

Table

In vitro susceptibility to standard antimalarial drugs of a fresh isolate of Plasmodium falciparum and after culture adaptation in comparison with P. falciparum 3D7 clone tested with the same plate batches*

Antimalarial drug


Fresh isolate IC50, nmol/L


Cultured isolate IC50, nmol/L, mean ± SD†


3D7 clone IC50, nmol/L, mean ± SD


IC50, isolate:3D7


Resistance cutoff value, nmol/L


Quinine

1,019

1,087 ± 145

171 ± 26

6.0:6.4

>800

Chloroquine

427

492 ± 39

13.9 ± 2.2

30.7:35.4

>100

Monodesethylamodiaquine

157

157 ± 27

16.3 ± 3.5

9.6:9.6

>80

Mefloquine

16.4

14.9 ± 2.2

53.4 ± 5.2

0.31:0.28

>30

Lumefantrine

8.9

9.0 ± 3.0

46.0 ± 6.0

0.19:0.20

>150

Pyronaridine

45.2

37.8 ± 8.4

18.3 ± 1.6

2.5:2.1

ND

Piperaquine

80.4

99.5 ± 11.7

56.3 ± 5.4

1.4:1.8

ND

Dihydroartemisinin

2.18

2.46 ± 0.28

2.58 ± 0.13

0.84:0.95

>10.5

Artesunate

1.86

1.68 ± 0.28

2.27 ± 1.15

0.82:0.74

>10.5

Atovaquone

6.5

5.2 ± 0.8

4.2 ± 0.7

1.5:1.2

>490

Doxycycline


11,600


12,600 ± 1,700


12,600 ± 1,000


0.92:1.0


>35,000


*Isolate was obtained from a man who returned to France from French Guiana in June 2010. IC50, 50% inhibitory concentration; ND, not determined.
†Mean IC50 and standard deviation of 3 different tests on the isolate after culture adaptation.

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