Volume 18, Number 11—November 2012
Dispatch
Susceptibility of Children to Sapovirus Infections, Nicaragua, 2005–2006
Filemón Bucardo1, Beatrice Carlsson1, Johan Nordgren, Göran Larson, Patricia Blandon, Samuel Vilchez, and Lennart Svensson
Table 2
Distribution of ABO blood groups, Lewis antigens, and FUT2 428 genotypes among SaV- infected children and healthy controls, León, Nicaragua, 2005–2006*
| Variable | No. (%) SaV infected | No. (%) controls† | OR (95% CI) | p value‡ |
|---|---|---|---|---|
| Blood group | ||||
|
O |
16 (73) | 87 (66) | 1.3 (0.49–3.7) | 0.63 |
|
A |
2 (9) | 26 (20) | 0.4 (0.09–1.8) | 0.37 |
|
B |
3 (13.5) | 13 (10) | 1.4 (0.37–5.5) | 0.82 |
|
AB |
1 (4.5) | 5 (4) | 1.2 (0.13–11) | 1.00 |
| Lewis phenotype | ||||
|
Lea-b+ |
17 (77.5) | 93 (71) | 1.3 (0.46–3.91) | 1.00 |
|
Lea+b- |
2 (9) | 5 (4) | 2.5 (0.45–13.7) | 0.26 |
|
Lea-b- |
3 (13.5) | 32 (25) | 0.48 (0.13−1.7) | 0.41 |
| FUT2 SNP (428G→A) | ||||
|
SeSe |
13 (59) | 69 (53) | 1.3 (0.52–3.2) | 0.64 |
|
Sese428 |
7 (32) | 58 (44) | 0.59 (0.22–1.5) | 0.35 |
|
se428se428 |
2 (9) | 4 (3) | 3.2 (0.55–18.00) | 0.2 |
| Secretor status | ||||
|
Secretor |
20 (91) | 123 (94) | 0.65 (0.13–3.3) | 0.63 |
|
Nonsecretor |
2 (9) | 8 (6) | 1.5 (0.3–7.8) | 0.63 |
*SaV, sapovirus; OR, odds ratio; FUT2, fucosyltransferase gene 2; SNP, single nucleotide polymorphism; SeSe, homozygous wild type at FUT2 428; Sese428, heterozygous carrier of FUT2 428 non-sense mutation; se428se428, homozygous carrier of the non-sense mutation at nt 428 in the FUT2 gene
†From Bucardo et al. (14).
‡Fischer exact test.
1These authors contributed equally to this article.
