Figure 3. . . Overview of spatiotemporal dispersal of dengue virus type 4 (DENV-4) from Southeast (SE) Asia to the Caribbean region and then to South America. Links between geographic locations represent phylogeny branches of the full genome maximum clade credibility tree, as projected by using SPREAD software (20). The blue-red gradient is coded to the arrows and depicts the relative time that has elapsed since the earliest inferred viral migration out of Southeast Asia (i.e., 1978, 95% Bayesian credible interval 1977–1980). Introductions are numbered as in Figure 1. Green indicates the presence of DENV-4 where complete genomic sequence data were available; yellow indicates sampled countries where complete genomic sequence data were available; gray, indicates no genomic data available; and circles indicate sampled locations and are colored according to the earliest migration that was detected from the sink location. RO, Roraima State; AMA, Amazonas State.