Figure. . . Phylogenetic relationships of human enterovirus C (HEV-C) and the new strain EV-C117 (dot), as determined on the basis of the complete capsid protein coding region sequences. The phylogeny of the nucleotide sequences was reconstructed by using maximum likelihood methods with the Tamura 3-parameter model as the evolutionary model rates among sites were heterogeneous, and gamma distribution was used for the relative rate (7). Branch support was assessed by means of bootstrap analyses of 1,000 replicates; a bootstrap value of 70% was used as the cutoff point for cluster analysis. Enterovirus strains EV-68 and EV-70 were used as the outgroup. Scale bar indicates nucleotide substitutions per site.