Volume 18, Number 3—March 2012
Dispatch
Escherichia coli O104:H4 Infections and International Travel
David C. Alexander, Weilong Hao, Matthew W. Gilmour, Sandra Zittermann, Alicia Sarabia, Roberto G. Melano, Analyn Peralta, Marina Lombos, Keisha Warren, Yuri Amatnieks, Evangeline Virey, Jennifer H. Ma, Frances B. Jamieson, Donald E. Low, and Vanessa G. Allen
Table
Virulence loci of ON-2011, ON-2010, and EAEC strain 55989*
| Gene product | Function | Presence in ON-2011 | Presence in ON-2010 | Presence in EAEC 55989 |
|---|---|---|---|---|
| STEC | ||||
| stx1 | Shiga toxin 1 | – | –- | – |
| stx2 | Shiga toxin 2 | + | – | – |
| EHEC-hlyA | EHEC hemolysin | – | – | – |
| cdt(I–V) | Cytolethal distending toxin | – | – | – |
| subAB | Subtilase cytotoxin | – | – | – |
| espP | Serine protease EspP | – | – | – |
| eae | Intimin | – | – | – |
| iha | Iha (IrgA homologue adhesin) | + | Partial (5′ end 21%) | + |
| lpfAO26 | Structural subunit of LPF of STEC O26 | + | + | + |
| lpfAO113 | Structural subunit of LPF of STEC O113 | + | + | + |
| lpfAO157–OI141 | Structural subunit of LPF of STEC O157:H7 (encoded on O island 141) | – | – | – |
| lpfAO157–OI154 | Structural subunit of LPF of STEC O157:H7 (encoded on O island 154) | – | – | – |
| saa | Saa (STEC autoagglutinating adhesin) | – | – | – |
| sfpA | Structural subunit of Sfp fimbriae | – | – | – |
| ter cluster | Tellurite resistance | + | – | – |
| irp2 | Component of iron uptake system on HPI | + | + | + |
| fyuA | Component of iron uptake system on HPI | + | + | + |
| EAEC | ||||
| aatA | EAEC virulence plasmid (pAA) | + | + | + |
| aggA | Pilin subunit of aggregative adherence fimbriae I (AAF/I) | + | – | – |
| agg3A | Pilin subunit of AAF/III | – | + | + |
| aggR | Transcriptional regulator AggR | + | + | + |
| aap | Dispersin | + | + | + |
| set1 | Shigella enterotoxin 1 | + | + | + |
| pic | Pic (protein involved in intestinal colonization) | + | + | + |
| astA | EAEC heat-stable enterotoxin 1 (EAST1) | – | + | + |
| EPEC | ||||
| bfpA | Bundle-forming pili | – | – | – |
| ETEC | ||||
| elt | Heat-labile enterotoxin (LT) | – | – | – |
| estla | Heat-stable enterotoxin (STIa) | – | – | – |
| estlb | Heat-stable enterotoxin (STIb) | – | – | – |
| EIEC | ||||
| ial | Invasive plasmid (pInv) | – | – | – |
*Derived from (11). EAEC, enteroaggregative Escherichia coli; STEC, Shiga- toxigenic E. coli; EHEC, enterohemorrhagic; LPF, long polar fimbriae; EPEC, enteropathogenic E. coli; ETEC, enterotoxigenic E. coli; EIEC, enterinvasive E. coli.
