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Volume 18, Number 4—April 2012

Research

Identification of Intermediate in Evolutionary Model of Enterohemorrhagic Escherichia coli O157

Christian Jenke, Shana R. Leopold, Thomas Weniger, Jörg Rothgänger, Dag Harmsen, Helge Karch, and Alexander MellmannComments to Author 
Author affiliations: Institute for Hygiene and National Consulting Laboratory on Hemolytic Uremic Syndrome, Münster, Germany (C. Jenke, S.R. Leopold, H. Karch, A. Mellmann); University Hospital Münster Periodontology, Münster (T. Weniger, D. Harmsen); Ridom GmbH, Münster (J. Rothgänger)

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Table

Fifty strains used for SNP typing of enterohemorrhagic Escherichia coli O157*

Strain ID Year of isolation Illness SF status and serotype Subgroup/cluster† Reference and/or GenBank accession no.
TB182A‡ 1991 D SF O55:H7 A (12)
CB9615‡ 2003 D SF O55:H7 A NC_013941
493/89‡ 1989 HUS SF O157:H B (16)
87–14‡ 1987 HUS NSF O157:H7 C1 (12)
EC4115‡ 2006 BD NSF O157:H7 C1 NC_011353
TW14359‡ 2006 BD NSF O157:H7 C1 NC_013008 (12,17)
TW14588‡ 2006 BD NSF O157:H7 C3 NZ_ABKY00000000.2
86–24‡ 1986 HUS NSF O157:H7 C2 (12)
Sakai‡ 1996 D NSF O157:H7 C3 NC_002695 (18)
EDL933‡ 1983 NA NSF O157:H7 C3 (14)
LSU-61 2001 NA SF O157:H7 Unknown intermediate (10,13)
SNPO157_01 1987 HUS NSF O157:H7 C1 This study
SNPO157_02 1988 D NSF O157:H7 C1 This study
SNPO157_03 1988 HUS SF O157:H B This study
SNPO157_04 1990 HUS NSF O157:H7 C1 This study
SNPO157_05 1991 HUS NSF O157:H C3 This study
SNPO157_06 1992 HUS NSF O157:H7 C3 This study
SNPO157_07 1993 HUS NSF O157:H7 C1 This study
SNPO157_08 1995 HUS NSF O157:H7 C1 This study
SNPO157_09 1995 HUS SF O157:H B This study
SNPO157_10 1996 HUS NSF O157:H C1 This study
SNPO157_11 1996 HUS SF O157:H B This study
SNPO157_12 1996 HUS SF O157:H B This study
SNPO157_13 1996 HUS NSF O157:H7 C1 This study
SNPO157_14 1997 HUS NSF O157:H7 C1 This study
SNPO157_15 1997 HUS NSF O157:H7 C1 This study
SNPO157_16 1998 HUS NSF O157:H7 C1 This study
SNPO157_17 1999 HUS NSF O157:H7 C1 This study
SNPO157_18 1999 HUS NSF O157:H7 C3 This study
SNPO157_19 2000 HUS NSF O157:H7 C1 This study
SNPO157_20 2000 D NSF O157:H7 C3 This study
SNPO157_21 2001 HUS SF O157:H B This study
SNPO157_22 2001 HUS NSF O157:H C3 This study
SNPO157_23 2002 D NSF O157:H7 C3 This study
SNPO157_24 2002 A NSF O157:H7 C1 This study
SNPO157_25 2003 HUS NSF O157:H7 C3 This study
SNPO157_26 2004 HUS NSF O157:H7 C1 This study
SNPO157_27 2005 HUS NSF O157:H7 C3 This study
SNPO157_28 2005 BD NSF O157:H7 C3 This study
SNPO157_29 2005 HUS NSF O157:H7 C1 This study
SNPO157_30 2006 HUS NSF O157:H7 C3 This study
SNPO157_31 2007 HUS NSF O157:H7 C3 This study
SNPO157_32 2007 HUS NSF O157:H7 C3 This study
SNPO157_33 2008 HUS NSF O157:H7 C3 This study
SNPO157_34 2008 D SF O157:H B This study
SNPO157_35 2008 HUS SF O157:H B This study
SNPO157_36 2009 D NSF O157:H7 § This study
SNPO157_37 2009 HUS SF O157:H B This study
SNPO157_38 2010 HUS NSF O157:H7 C3 This study
SNPO157_39 2010 HUS SF O157:H B This study

*All strains were isolated from humans except strain LSU-61, which was isolated from a deer (10), and EDL933, which was isolated from food (14). Strains isolated from humans were categorized into 3 subgroups (11,12); subgroup A represents isolates of serotype O55:H7, subgroup B SF O157:H– isolates, and subgroup C NSF O157:H7. Subgroup C is subdivided into clusters 1–3. SNP, single-nucleotide polymorphism; ID, identification; SF, sorbitol fermenting; D, diarrhea; HUS, hemolytic uremic syndrome; NSF, non-SF; BD, bloody diarrhea; NA, not applicable; A, asymptomatic.
†Subgroup and, if applicable, cluster designation based on 4 SNP loci (Sakai genome positions 337933, 1460599, 2370797, and 5404166) and the occupancy of potential stx integration sites in accordance with (11,12,15). Boldface indicates cluster designation of prototype strains.
‡Strains were analyzed in silico.
§SNP pattern for NSF O157:H7 grouping resulted in an unknown combination.

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