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Volume 19, Number 10—October 2013
Research

Immunogenic Mycobacterium africanum Strains Associated with Ongoing Transmission in The Gambia

Florian GehreComments to Author , Martin Antonio, Jacob K. Otu, Neneh Sallah, Oumie Secka, Tutty Faal, Patrick Owiafe, Jayne S. Sutherland, Ifedayo M. Adetifa, Martin O. Ota, Beate Kampmann, Tumani Corrah, and Bouke C. de Jong
Author affiliations: Medical Research Council Unit, Fajara, The Gambia (F. Gehre, M. Antonio, J.K. Otu, N. Sallah, O. Secka, T. Faal, P. Owiafe, J.S. Sutherland, I.M. Adetifa, M.O. Ota, B. Kampmann, T. Corrah, B.C. de Jong); Institute for Tropical Medicine, Antwerp, Belgium (F. Gehre, B.C. de Jong); Imperial College London, London, UK (B. Kampmann); New York University, New York, New York, USA (B.C. de Jong)

Main Article

Table 1

Spoligotyping results for comparative population structure of Mycobacterium tuberculosis sensu stricto (including EA), the EA clade separately, and M. africanum, The Gambia, 2002–2009

Parameters M. tuberculosis sensu stricto
 M. africanum
 Total
All lineages EA clade Afri_1
 Afri_2
With SIT 181 Without SIT 181
Population parameters
No. isolates (n) 548 467 334 136 2 884
No. genotypes 108 79 63 62 2 173
No. singletons (s) 60 43 41 41 2 103
No. clusters (c) 48 36 22 21 NA 70
Clustering rate, (n − s)/n 0.89 0.91 0.88 0.70 NA 0.88
Average cluster size, (n − s)/c 10.2 11.8 13.3 4.3 NA 11.2
Genetic diversity
 40.0
 27.0
22.7
 43.4
 NA
 64.0
Recent transmission index 0.80 0.83 0.81 0.54 NA 0.80

*EA, Euro-American; SIT, shared international type; NA, not applicable.

Main Article

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