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Volume 19, Number 10—October 2013

Research

Immunogenic Mycobacterium africanum Strains Associated with Ongoing Transmission in The Gambia

Florian GehreComments to Author , Martin Antonio, Jacob K. Otu, Neneh Sallah, Oumie Secka, Tutty Faal, Patrick Owiafe, Jayne S. Sutherland, Ifedayo M. Adetifa, Martin O. Ota, Beate Kampmann, Tumani Corrah, and Bouke C. de Jong
Author affiliations: Medical Research Council Unit, Fajara, The Gambia (F. Gehre, M. Antonio, J.K. Otu, N. Sallah, O. Secka, T. Faal, P. Owiafe, J.S. Sutherland, I.M. Adetifa, M.O. Ota, B. Kampmann, T. Corrah, B.C. de Jong); Institute for Tropical Medicine, Antwerp, Belgium (F. Gehre, B.C. de Jong); Imperial College London, London, UK (B. Kampmann); New York University, New York, New York, USA (B.C. de Jong)

Main Article

Table 4

PPD ELISPOT results for blood samples from patients infected with Mycobacterium tuberculosis sensu stricto (including EA lineage), M. tuberculosis EA lineage, and M. africanum strains, The Gambia, 2002–2007*

Clustered Singleton Total χ2 test† Fisher exact test‡
M. tuberculosis
Positive 182 19 201 1.65 (0.57–4.77) 0.3495 0.2533
Negative 29 5 34 0.61 (0.21–1.75) 0.3495 0.2533
Total
211
24
235



M. tuberculosis EA
Positive 149 14 163 1.58 (0.48–5.15) 0.4479 0.3184
Negative 27 4 31 0.63 (0.19–2.07) 0.4479 0.3184
Total
176
18
194



M. africanum
Positive 110 9 119 31.78 (9.24–109.28) 0.0001 0.0001
Negative 5 13 18 0.03 (0.01–0.11) 0.0001 0.0001
Total
115
22
137



M. africanum SIT 181
Positive 73 9 82 21.09 (6.09–73.04) 0.0001 0.0001
Negative 5 13 18 0.05 (0.01–0.16) 0.0001 0.0001
Total 78 22 100

*PPD, purified protein derivative; EA, Euro-American.
†2-tailed.
‡1-tailed.

Main Article

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