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Volume 19, Number 10—October 2013

Dispatch

Primary Multidrug-Resistant Mycobacterium tuberculosis in 2 Regions, Eastern Siberia, Russian Federation

Svetlana Zhdanova1, Scott K. Heysell1Comments to Author , Oleg Ogarkov, Galina Boyarinova, Galina Alexeeva, Suporn Pholwat, Elena Zorkaltseva, Eric R. Houpt, and Eugeniy Savilov
Author affiliations: Russian Academy of Medical Sciences, Irkutsk, Russian Federation (S. Zhdanova, O. Ogarkov, E. Savilov); University of Virginia, Charlottesville, Virginia, USA (S.K. Heysell, G. Boyarinova, S. Pholwat, E.R. Houpt); Regional TB-Prevention Dispensary, Irkutsk (O. Ogarkov, E. Zorkaltseva); Research Practice Center for Phthisiatry, Yakutsk, Russian Federation (G. Alexeeva); State Medical Continuing Education Academy, Irkutsk (E. Zorkaltseva, E. Savilov)

Main Article

Table 1

Mycobacterium tuberculosis genotype, by region, eastern Siberia, Russian Federation*

MIRU-VNTR 12 Family/ MIT Irkutsk
p value Yakutia
p value
No. (%) total, n = 105 No. (%) MDR, n = 25 No. (%) total, n = 130 No. (%) MDR, n = 36
223325153533 Beijing 16 32 (31) 7 (28) <0.001 12 (9) 1 (3) 0.006
223325173533 Beijing 17 13 (12) 6 (24) 0.27 10 (8) 7 (19) 0.76
233325153325 S 256 0 0 <0.001 14 (11) 12 (33) 0.001
223125153324 T 8 0 0 NA 9 (7) 0 0.005
227225113223 Ural 171 0 0 NA 6 (5) 0 0.03
223325153433 Beijing 592 1 (1) 0 NA 4 (3) 0 0.38

*MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat (original 12-loci profile). Included genotypes found in >5 isolates only; MIT, MIRU–VNTR international type; MDR, multidrug-resistant tuberculosis (conventional resistance to isoniazid and rifampin); NA, not applicable. Significance determined by χ2 analysis with Yates correction or Fisher exact test when appropriate.

Main Article

1These authors contributed equally to this article.

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