Volume 19, Number 3—March 2013
Research
Emergence and Spread of Extensively and Totally Drug-Resistant Tuberculosis, South Africa
Marisa Klopper, Robin Mark Warren
, Cindy Hayes, Nicolaas Claudius Gey van Pittius, Elizabeth Maria Streicher, Borna Müller, Frederick Adriaan Sirgel, Mamisa Chabula-Nxiweni, Ebrahim Hoosain, Gerrit Coetzee, Paul David van Helden, Thomas Calldo Victor, and André Phillip Trollip
, Cindy Hayes, Nicolaas Claudius Gey van Pittius, Elizabeth Maria Streicher, Borna Müller, Frederick Adriaan Sirgel, Mamisa Chabula-Nxiweni, Ebrahim Hoosain, Gerrit Coetzee, Paul David van Helden, Thomas Calldo Victor, and André Phillip TrollipTable 2
Correlation of culture-based and molecular-based drug-susceptibility testing among atypical Beijing isolates, South Africa, 2008–2009*
| Drug/gene | CB-DST R, MB-DST R | CB-DST S, MB-DST S | CB-DST R, MB-DST S | CB-DST S, MB-DST R | Total | Correlation, % |
|---|---|---|---|---|---|---|
| INH/katG | 217 | 9 | 1 | 0 | 227 | 99.6 |
| RIF/rpoB | 219 | 9 | 0 | 0 | 228 | 100 |
| STR/rrs500 | 191 | 6 | 2 | 16 | 215 | 91.6 |
| EMB/embB | 56 | 5 | 2 | 152 | 215 | 28.4 |
| ETH/inhA promoter | 76 | 25 | 5 | 86 | 192 | 52.6 |
| OFL/gyrA | 78 | 93 | 0 | 29 | 200 | 85.5 |
| AMK/rrs1400 | 167 | 32 | 7 | 9 | 215 | 92.6 |
| CAP/rrs1400 | 21 | 38 | 1 | 155 | 215 | 27.4 |
*CB-DST, culture-based drug susceptibility testing; R, resistant; MB-DST, molecular-based DST; S, sensitive; INH, isoniazid; RIF, rifampin; STR, streptomycin; EMB, ethambutol; ETH, ethionamide; OFL, ofloxacin; AMK, amikacin; CAP, capreomycin.
