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Volume 19, Number 6—June 2013

Synopsis

Zoonotic Mycobacterium bovis–induced Tuberculosis in Humans

Borna MüllerComments to Author , Salome Dürr, Silvia Alonso, Jan Hattendorf, Cláudio J.M. Laisse, Sven D.C. Parsons, Paul D. van Helden, and Jakob Zinsstag
Author affiliations: Stellenbosch University, Cape Town, South Africa (B. Müller, S.D.C. Parsons, P.D. van Helden); Swiss Tropical and Public Health Institute, Basel, Switzerland (B. Müller, J. Hattendorf, J. Zinsstag); University of Basel, Basel (B. Müller, J. Hattendorf, J. Zinsstag); University of Berne, Berne, Switzerland (S. Dürr); Royal Veterinary College, Hertfordshire, UK (S. Alonso); Veterinary Faculty, Eduardo Mondlane University, Maputo, Mozambique (C. J. M. Laisse)

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Table 2

Overview of selected reports from Africa on zoonotic Mycobacterium bovis–induced TB in humans*

ID Country Setting Sampling Detection Years M. bovis TB‡ 95% CI Location
1131 Tanzania NA Conv. Mol. NA 20 53 37.7 24.8–52.1 EPTB
1131 Tanzania Arusha region Conv. Mol. 1994 4 11 36.4 10.9–69.2 EPTB
1074 Ethiopia Butajira health center, southeastern Ethiopia System. Mol. 2000/2001 11 35 31.4 16.9–49.3 EPTB
1074 Ethiopia NA Conv. Biochem. NA 14 48 29.2 17.0–44.1 PTB
15 Ethiopia Felegehiwot hospital Conv. Biochem. 2007/2008 8 47 17.0 7.6–30.8 Both
65 Ethiopia NA Conv. Biochem. NA 7 42 16.7 7.0–31.4 Both
1074 Ethiopia Fitche Hospital TB clinic Conv. Biochem. 2004/2005 7 42 16.7 7.0–31.4 Both
294 Tanzania Arusha region and Southern Highlands Surv. Biochem. 1993–1996 7 44 15.9 6.6–30.1 Both
73 Nigeria Jos Conv. Biochem. NA 10 65 15.4 7.6–26.5 PTB
68 Uganda Karamojo region Conv. Mol. NA 3 24 12.5 2.7–32.4 EPTB
159 Tanzania Three districts in Arusha region Surv. Biochem. 1999–2001 7 65 10.8 4.4–20.9 EPTB
459 Malawi Blantyre, Queen Elizabeth Central Hospital Conv. Biochem. NA 1 30 3.3 0.1–17.2 PTB
62 Ghana Korle-Bu Teaching Hospital Conv. Biochem. 2003 2 64 3.1 0.4–10.8 PTB
464 Madagascar Institut d'Hygiène Sociale, Antananarivo Conv. Mol. 1994 3 126 2.4 0.5–6.8 PTB
340 Madagascar Antananarivo Surv. Other 1994/1995 2 156 1.3 0.2–4.6 EPTB
292 Madagascar Antananarivo, Antsirabe, Fianarantsoa, and Mahajanga Rand. Mol. 1994/1995 4 316 1.3 0.3–3.2 PTB
243 Uganda Kampala Conv. Biochem. 1995–1997 1 234 0.4 0.0–2.4 PTB
52 Uganda Kampala, Rubaga division Surv. Mol. 2006 1 386 0.3 0.0–1.4 PTB
222 Cameroon Ouest Province Surv. Mol. 1997/1998 1 455 0.2 0.0–1.2 PTB
80 Burkina Faso Health centers in Ouagadougou and Bobo Dioulasso Conv. Mol. 2001 0 120 0.0 0.0–3.0¶ PTB
12 Burundi Bujumbara, Bubanza Hospital Conv. Mol. 1987–1994 0 117 0.0 0.0–3.1¶ Both
165 Chad Chari-Baguirmi Conv. Mol. 2002 0 10 0.0 0.0–30.8¶ Both
12 Côte d'Ivoire TB and rural health centers in Côte d’Ivoire Cluster Mol. 1994–1996 0 320 0.0 0.0–1.1¶ PTB
464 Madagascar Antananarivo prison Conv. Mol. 1994 0 36 0.0 0.0–9.7¶ PTB
12 Sierra Leone Western Area and Kenema districts Surv. Mol. 2003/2004 0 97 0.0 0.0–3.7¶ PTB
32 Uganda Mbarara district Rand. Mol. 2004/2005 0 70 0.0 0.0–5.1¶ Both

*TB, tuberculosis; ID, record identification number (Technical Appendix 2); NA, not available; Conv., convenience sample/not specified; Mol., molecular-based detection method; EPTB, extrapulmonary TB; System, systematic sampling; Biochem, biochemical detection method; PTB, pulmonary TB; Surv.,surveillance data; Rand., random sampling; Cluster, cluster sampling.
†Number of putative zoonotic cases of Mycobacterium bovis.
‡Total number of bacteriologically confirmed and characterized TB cases.
§%, proportion of zoonotic TB among all TB cases.
¶One-sided 97.5% CIs are indicated.

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