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Volume 19, Number 9—September 2013
Dispatch

Powassan Meningoencephalitis, New York, New York, USA

Simon Sung1Comments to Author , Alysse G. Wurcel1, Susan Whittier, Karen Kulas, Laura D. Kramer, Robin Flam, James Kirkland Roberts, and Simon Tsiouris
Author affiliations: Columbia University, New York City, New York, USA (S. Sung, A.G. Wurcel, S. Whittier, R. Flam, J.K. Roberts, S. Tsiouris); Tufts Medical Center, Boston, Massachusetts, USA (A.G. Wurcel); New York State Department of Health, Albany, New York, USA (K. Kulas, L.D. Kramer); Mid Hudson Medical Group, Hopewell Junction, New York, USA (R. Flam)

Main Article

Table

Results of initial arboviral serologic testing and POWV RT-PCR on CSF from 2 patients, performed at Wadsworth Center, New York State Department of Health, New York, USA*

Test Test result, month
Patient 1, 2009 Patient 2, 2012
West Nile virus IgM ELISA Nonreactive, Feb Nonreactive, May
Eastern equine encephalitis virus IgG IFA <16, Feb <16, May
Western equine encephalitis virus IgG IFA <16, Feb <16, May
California serogroup IgG IFA <16, Feb <16, May
St. Louis encephalitis virus IgG IFA <16, Feb <16, May
rPOW-E polyvalent MIA† (titer) Reactive, Feb Reactive, May
Powassan PRNT (titer) + (20), Feb + (280), early May
+ (320), Mar + (320), late May
+ (160), early Jun
+ (10), late Jun
Powassan RT-PCR CSF Not done –

*POWV, Powassan virus; RT-PCR, reverse transcription PCR; CSF, cerebrospinal fluid; IFA, immunofluorescent assay; MIA, microsphere immunoassay; PRNT, plaque reduction neutralizing test;; +, positive; –, negative.
†A fluorescent MIA technique using recombinant POWV envelope glycoprotein antigen to detect IgG, IgA, and IgM.

Main Article

1These authors contributed equally to this article.

Page created: August 20, 2013
Page updated: August 20, 2013
Page reviewed: August 20, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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