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Volume 23, Number 4—April 2017
Research

Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi

Paul C.S. DivisComments to Author , Lee C. Lin, Jeffrine J. Rovie-Ryan, Khamisah A. Kadir, Fread Anderios, Shamilah Hisam, Reuben S.K. Sharma, Balbir Singh, and David J. Conway
Author affiliations: Malaria Research Centre, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia (P.C.S. Divis, K.A. Kadir, B. Singh, D.J. Conway); London School of Hygiene and Tropical Medicine, London, United Kingdom (P.C.S. Divis, D.J. Conway); Universiti Putra Malaysia, Serdang, Malaysia (L.C. Lin, R.S.K. Sharma); Department of Wildlife and National Parks Peninsular Malaysia, Kuala Lumpur, Malaysia (J.J. Rovie-Ryan); Sabah State Public Health Laboratory, Kota Kinabalu, Malaysia (F. Anderios); Institute for Medical Research, Kuala Lumpur (S. Hisam)

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Figure 3

Subpopulation cluster assignments of individual Plasmodium knowlesi infections in human and macaque hosts across Malaysia and 7 laboratory isolates. The Bayesian-based STRUCTURE analysis with LOCPRIOR model (22) was applied on complete 10-microsatellite loci of 166 P. knowlesi infections and 7 laboratory isolates showing 3 subpopulation clusters (K = 3; ΔK = 37.72). Ancestral population clusters are referred to as cluster 1 (blue), cluster 2 (green), and cluster 3 (red). Numbers in parentheses i

Figure 3. Subpopulation cluster assignments of individual Plasmodium knowlesi infections in human and macaque hosts across Malaysia and 7 laboratory isolates. The Bayesian-based STRUCTURE analysis with LOCPRIOR model (22) was applied on complete 10-microsatellite loci of 166 P. knowlesi infections and 7 laboratory isolates showing 3 subpopulation clusters (K = 3; ΔK = 37.72). Ancestral population clusters are referred to as cluster 1 (blue), cluster 2 (green), and cluster 3 (red). Numbers in parentheses indicate number of isolates. hm, human; lt, long-tailed macaque; pt, pig-tailed macaque; ot, various other sources.

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