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Volume 3, Number 2—June 1997

Synopsis

Polycystic Kidney Disease: An Unrecognized Emerging Infectious Disease?

Marcia A. Miller-Hjelle*, J. Thomas Hjelle*, Monica Jones*, William R. Mayberry†, Mary Ann Dombrink-Kurtzman‡, Stephen W. Peterson‡, Deborah M. Nowak*, and Frank S. Darras*
Author affiliations: *University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA; †East Tennessee State University, Johnson City, Tennessee, USA; ‡U.S. Department of Agriculture, Agricultural Research Service, Peoria, Illinois, USA

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Table 1

Limulus assay results from human kidney cyst fluids

Donor No. Patient data No. Cysts
Tested Cysts ET positive (%):
Endotoxin units/mla Cysts ß-D-glucan positive (%): pg/ml
1 ADb 45 yr F 5 3 (60%): 0.48 EU/ml ndc
2 AD 52 yr F 6 4 (67%): 1.71 EU/ml nd
3 AD 48 yr M Ld 9 5 (56%): 1.45 EU/ml nd
Re 11 6 (55%): 2.27 EU/ml nd
4 AD 41 yr F 16 3 (19%): 0.88 EU/ml 3 (19%): 120 pg/ml
5 AD 37 yr M 11 2 (18%): 3.84 EU/ml 6 (55%): 106 pg/ml
6 PDf AD 43 yr F 13 4 (31%): 0.26 EU/ml nd
7 ARg 5 wk M pool(8) 3.84 EU/ml nd
8 SCh 48 yr F 1(200ml) 3.84 EU/ml nd

aMean EU/ml or pg (13)ßD-glucan/ml
bAutosomal-dominant polycystic kidney disease (PKD)
cNot detected
dLeft kidney
eRight kidney
fPeritoneal dialysis
gAutosomal recessive PKD
hSimple kidney cyst (not PKD)

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