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Volume 3, Number 2—June 1997

Synopsis

Polycystic Kidney Disease: An Unrecognized Emerging Infectious Disease?

Marcia A. Miller-Hjelle*, J. Thomas Hjelle*, Monica Jones*, William R. Mayberry†, Mary Ann Dombrink-Kurtzman‡, Stephen W. Peterson‡, Deborah M. Nowak*, and Frank S. Darras*
Author affiliations: *University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA; †East Tennessee State University, Johnson City, Tennessee, USA; ‡U.S. Department of Agriculture, Agricultural Research Service, Peoria, Illinois, USA

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Table 2

Serologic results of five cyst fluids from three autosomal-dominant PKD patients tested for fungal antigens or antibodies to fungal components

Donor;Cyst No. LALa Findings Serologic Findings
D6;1 Neg. Etb;Neg. ß-DGc Antigens not detected
D6;2 Neg. ET;Neg. ß-DG IgE and IgG reactive with fungi were not detected
D4;3 Neg. ET;Pos. ß-DG Antigens: Fusarium solani at 1:2 dilution; Aspergillus galactomannan at >50 ng/ml
D5;4 Neg. ET;Pos. ß-DG Antigens: Aspergillus galactomannan at >50 ng/ml;
Candida albicans serotype A mannan at 10 ng/ml
D5;5 Neg. ET;Pos. ß-DG IgE reactive with Fusarium moniliforme; C. albicans
(weak positive)

aLimulus amebocyte lysate assay
bEndotoxin
cß-D-glucan

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