Volume 3, Number 2—June 1997
Synopsis
Borna Disease
Carolyn G. Hatalski, Ann J. Lewis, and W. Ian Lipkin
Table 2
Borna disease virus nucleic acid in patients with various diseases
| Prevalence |
|||||||
|---|---|---|---|---|---|---|---|
| Disease | Tissue | Disease | (%) | Controls | (%) | Divergence* | Ref. |
| Psychiatric | PBMC | (4/6) | 66.7 | (0/10) | 0 | 0-3.6 | (22) |
| (various) | PBMC | (5/12) | 41.7 | (0/23) | 0 | 0-4 | (27) |
| PBMC | (22/60) | 37 | (8/172) | 4.7 | (24, 25) | ||
| PBMC-coculture | (3/32) | 9.4 | (0/5) | 0 | 0.07-0.83 | (23, 53) | |
| Affective | PBMC | (1/3) | 33.3 | (0/23) | 0 | (27) | |
| PBMC | (1/6) | 16.7 | (0/36) | 0 | (51) | ||
| PBMC | (0/9) | 0 | (56) | ||||
| Schizophrenia | PBMC | (7/11) | 63.6 | (0/23) | 0 | (27) | |
| PBMC | (5/49) | 10.2 | (0/36) | 0 | (51) | ||
| PBMC | 4.2-9.3 | (54) | |||||
| Brain | (0/3) | 0 | (0/3) | 0 | (55) | ||
| CSF | (0/48) | 0 | (0/9) | 0 | (55) | ||
| PBMC | (0/9) | 0 | (0/9) | 0 | (55) | ||
| PBMC | (0/26) | 0 | (56) | ||||
| CFS | PBMC | (3/25) | 12 | 6.0-14 | (26) | ||
| Hippocampal sclerosis | Brain | (4/5) | 80 | (53) | |||
Abbreviations: PBMC, peripheral blood mononuclear cells; CSF, cerebrospinal fluid; CFS, chronic fatigue syndrome.
*Divergence of P-gene nucleotide sequence from common BDV isolates (strain V [4] and He/80 [9]).
