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Volume 3, Number 3—September 1997

Synopsis

Borna Disease Virus Infection in Animals and Humans

Jürgen A. Richt*Comments to Author , Isolde Pfeuffer*, Matthias Christ*, Knut Frese†, Karl Bechter‡, and Sibylle Herzog*
Author affiliations: *Institut für Virologie, Giessen, Germany; †Institut für Veterinär-Pathologie, Giessen, Germany; and ‡Universität Ulm, Günzburg, Germany

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Table 1

Adoptive transfer of Borna disease virus (BDV) TH1 cells before and after BDV infection

Group CY treatment Transfer of TH1-cells Clinical BD
Control yes day +10 no
BDV yes no no
BDV no day +10 yes
BDV yes day +3 yes
BDV yes day +10 yes
BDV no day -25 and -5 no

Four-week-old Lewis rats were inoculated intracerebrally with BDV; some rats were treated with cyclophosphamide (CY) (150 mg/kg) for immunosuppression 24 hours later. Animals were intravenously injected with >2x106 BDV-specific TH1 cells on the indicated days, either before (-) or after (+) infection with BDV.

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