Emerging Infectious Disease ISSN: 1080-6059

Multidrug-Resistant Mycobacterium tuberculosis: Molecular Perspectives

Ashok Rattan

, Awdhesh Kalia

, and Nishat Ahmad

Author affiliations: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

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Figure 3

Single amino acid substitutions in the 81 bp core-region of the rpoB gene responsible for conferring rifampicin (RIF) resistance (Insertions and deletions that confer the RIF-resistance phenotype are not depicted). Amino acids are represented with single letter abbreviations. Changes in codon Ser531 and His526 account for more than 70% of the mutations with RIF resistance (depicted in shaded ellipses).

Figure 3. Single amino acid substitutions in the 81 bp core-region of the rpoB gene responsible for conferring rifampicin (RIF) resistance (Insertions and deletions that confer the RIF-resistance phenotype are not depicted). Amino acids are represented with single letter abbreviations. Changes in codon Ser531 and His526 account for more than 70% of the mutations with RIF resistance (depicted in shaded ellipses).

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