Volume 4, Number 2—June 1998
Perspective
Multidrug-Resistant Mycobacterium tuberculosis: Molecular Perspectives
Ashok Rattan
, Awdhesh Kalia , and Nishat Ahmad
, Awdhesh Kalia , and Nishat AhmadTable
Gene loci involved in conferring drug-resistance in Mycobacterium tuberculosis
| Drug | Gene | Product | Reported frequency in resistant strainsa (%) | Reference |
|---|---|---|---|---|
| Rifampicin | rpoB | B-subunit of RNA polymerase | >95 | 45-48,68-71 |
| Isoniazid | katG | Catalase-peroxidase | 60-70 | 39-48 |
| oxyR-ahpC | Alky hydro-reductase | ~20 | 36 | |
| INH-Ethionamide | inhA | Enoyl-ACP reductase | <10 | 46-48 |
| Streptomycin | rpsL | Ribosomal protein S12 | 60 | 46-48 |
| rrs | 16s rRNA | <10 | 113-117 | |
| Fluoroquinolone | gyrA | DNA gyrase | >90 | 107 |
| Pyrazinamide | pncA | Amidase | 70-100 | 92-94 |
| Ethambutol | embCAB | EmbCAB | 69 | 88 |
aMutation frequencies are as determined by sequencing and polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis.
