Emerging Infectious Disease ISSN: 1080-6059

Multiple-Drug Resistant Enterococci: The Nature of the Problem and an Agenda for the Future

Mark M. Huycke*†, Daniel F. Sahm‡, and Michael S. Gilmore†

Author affiliations: *University of Oklahoma Health Sciences Center, Oklahoma, USA; †Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA; ‡MLR Pharmaceutical Services, Inc., Reston, Virginia, USA

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Figure 3

Cytolysin favors the appearance of circulating enterococci. In this experiment, 107 CFU of E. faecalis, either cytolytic FA2-2(pAM714) (60) or noncytolytic FA2-2(pAM771) (64), were intraperitoneally injected (45) into groups of five BalbC mice. Viable bacteria in liver, spleen, and the bloodstream were enumerated 48 hrs following injection, and significance assessed by Student's t-test. (P. Coburn, L.E. Hancock, and M.S. Gilmore, in preparation).

Figure 3. Cytolysin favors the appearance of circulating enterococci. In this experiment, 10⁷ CFU of E. faecalis, either cytolytic FA2-2(pAM714) (60) or noncytolytic FA2-2(pAM771) (64), were intraperitoneally injected (45) into groups of five BalbC mice. Viable bacteria in liver, spleen, and the bloodstream were enumerated 48 hrs following injection, and significance assessed by Student's t-test. (P. Coburn, L.E. Hancock, and M.S. Gilmore, in preparation).

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