Volume 5, Number 1—February 1999
Perspective
Socioeconomic and Behavioral Factors Leading to Acquired Bacterial Resistance to Antibiotics in Developing Countries
Iruka N. Okeke*, Adebayo Lamikanra*, and Robert Edelman†
Table 2
Source and quality of tetracycline capsules in a Nigerian suburban town (compiled with data from [53])
| Sample | Source | Tetracycline content (% of label claim) | Content of ATCa (%) | Bioavailability (%)b |
|---|---|---|---|---|
| C1 | Manufacturerc | 105.9 | None detected | 100 |
| C2 | Hospital | 107.5 | 5.3 | 63.4d |
| C3 | Roadside stall | 104.5 | 1.1 | 80.5d |
| C4 | Pharmacy | 66.1 | 2.4 | 65.2d |
| C5 | Patent medicine stall | 84.5 | 1.9 | 87.6d |
| C6 | Roadside stall | 67.8 | 1.5 | Not tested |
| C7 | Patent medicine stall | 89.6 | 1.8 | Not tested |
aAnhydrotetracycline, one of four tetracycline degradation products.
bMeasured from cumulative excretion of tetracycline in the urine of five volunteers.
cReference standard obtained from the manufacturer.
dSignificantly different from C1 (p = 0.01, Wilcoxon signed rank test).
