Emerging Infectious Disease ISSN: 1080-6059

Rapid Molecular Genetic Subtyping of Serotype M1 Group A Streptococcus Strains

Nancy Hoe*, Kazumitsu Nakashima*, Diana Grigsby*, Xi Pan*, Shu Jun Dou*, Steven Naidich†, Marianne Garcia‡, Emily Kahn‡, David Bergmire-Sweat‡, and James M. Musser*

Author affiliations: *Baylor College of Medicine, Houston, Texas, USA; †Naidich Space Laboratory, Inc., New York, New York, USA; ‡Texas Department of Health, Austin, Texas, USA

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Figure 2

Variation in the sic gene and Sic protein identified in M1 group A Streptococcus isolates characterized in the study. The figure is a compilation of variations found in the 15 distinct sic alleles in the sample. The numbers at the top of the figure refer to the nucleotide sequence position of a sic allele described in reference 6. Single-letter amino acid abbreviations are used. SRR, amino-terminal short repeat region; Roman numeral, short repeats I-V which recur in SRR; R2 and R3, tandem repeat

Figure 2. Variation in the sic gene and Sic protein identified in M1 group A Streptococcus isolates characterized in the study. The figure is a compilation of variations found in the 15 distinct sic alleles in the sample. The numbers at the top of the figure refer to the nucleotide sequence position of a sic allele described in reference 6. Single-letter amino acid abbreviations are used. SRR, amino-terminal short repeat region; Roman numeral, short repeats I-V which recur in SRR; R2 and R3, tandem repeats; MGAS strain, Musser Group A Streptococcus strain number; X, presence of polymorphism.

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