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Volume 5, Number 2—April 1999

Dispatch

Lack of Association between First Myocardial Infarction and Past Use of Erythromycin, Tetracycline, or Doxycycline

Lisa A. JacksonComments to Author , Nicholas L. Smith, Susan R. Heckbert, J. Thomas Grayston, David S. Siscovick, and Bruce M. Psaty
Author affiliations: University of Washington, Seattle, Washington, USA

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Table 2

Cumulative duration of prescribed treatment with erythromycin, tetracycline, doxycycline, and the three agents combined, and the risk for incident myocardial infarction

Drug Cumulative
duration
(day)a Case-patients 
(n=1796) (%) Controls
(n=4882) (%) ORb
(95% CI) ORc
(95% CI)
Erythromycin 0 1,266 (70) 3,493 (72) 1.0 reference 1.0 reference
1-14 401 (22) 1,124 (23) 0.99 (0.87-1.13) 0.91 (0.79-1.05)
15-28 92 (5) 182 (4) 1.41 (1.08-1.82) 1.18 (0.89-1.54)
29+ 37 (2) 83 (2) 1.23 (0.83-1.83) 1.05 (0.69-1.59)
Tetracycline 0 1,507 (84) 4,149 (85) 1.0 reference 1.0 reference
1-14 223 (12) 564 (12) 1.11 (0.94-1.31) 1.02 (0.86-1.22)
15-28 39 (2) 88 (2) 1.24 (0.84-1.81) 1.04 (0.69-1.55)
29+ 27 (2) 81 (2) 0.95 (0.61-1.47) 0.98 (0.62-1.54)
Doxycycline 0 1,597 (89) 4,365 (89) 1.0 reference 1.0 reference
1-14 37 (2) 86 (2) 1.18 (0.79-1.74) 1.06 (0.71-1.59)
15-28 85 (5) 244 (5) 0.94 (0.73-1.22) 0.90 (0.69-1.18)
29+ 77 (4) 187 (4) 1.10 (0.84-1.45) 1.17 (0.88-1.56)
Erythromycin 0 1,021 (57) 2,821 (58) 1.0 reference 1.0 reference
tetracycline 1-14 422 (24) 1,178 (24) 0.99 (0.87-1.14) 0.93 (0.81-1.07)
or doxycycline 15-28 185 (10) 454 (9) 1.13 (0.94-1.35) 0.99 (0.81-1.20)
29+ 168 (9) 421 (9) 1.11 (0.91-1.34) 1.03 (0.84-1.26)

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