Volume 5, Number 3—June 1999
The Cost Effectiveness of Vaccinating against Lyme Disease
|Base treatment costsb x 0.5
||Base treatment costsc||Base treatment costsb x 1.5
|Probability of Lyme disease||Vaccine effectivenessd
|(23,527; 22,556)||(17,947; 16,927)||(17,283; 15,261)||(17,249;14,286)||(11,641;8,703)|
|(10,178; 9197)||(7,372; 6,412)||(5,531; 3,487)||(3,846; 958)||(1,220; savee)|
|0.03||795||Net savingse||Net savingse||Net savingse||Net savingse|
|(1,303; 330)||(385; savee)||(save; savee)||(save; savee)||(save; savee)|
aThese results were generated by setting the probability of detecting and successfully treating early Lyme disease at 0.80 and the cost of vaccination at $100 per year.
bBase treatment costs are given in Table 2. The data presented in this table were generated by multiplying the costs in Table 2 by either 0.5 (i.e., reducing costs by half) or by 1.5 (i.e. increasing costs by half).
cFor comparison, the results using the base costs (Table 2) are presented here, assuming a vaccine effectiveness of 0.85. Figure 2 presents the complete set of results using the base costs.
dThe initial assumed level of vaccine effectiveness was 0.85 (Figure 2).
eNet savings are generated when a person is vaccinated against Lyme disease and the costs saved by not having to treat a case of Lyme disease are higher than the costs of vaccination plus the costs of having to treat a case of Lyme disease that occurs after vaccination. The net savings range from $140 (probability of Lyme disease = 0.03, vaccine effectiveness = 0.95, cost of treating Lyme disease sequelae = 0.5 x base costs) to $7,438 (probability of Lyme disease = 0.03, vaccine effectiveness = 0.95, cost of treating Lyme disease sequelae =1.5 x base costs). Note also that in some instances where mean net savings are calculated, the 5th percentiles are net costs.