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Volume 5, Number 3—June 1999

Synopsis

Human Herpesvirus 6: An Emerging Pathogen

Gabriella Campadelli-FiumeComments to Author , Prisco Mirandola, and Laura Menotti
Author affiliations: University of Bologna, Bologna, Italy

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Table

Epidemiology and distribution of human herpesvirus (HHV-6) variants

Variant A Variant B
Associated pathologic conditions
Exanthem subitum febrile syndromesb _a ++++
Multiple sclerosis ++ ++
Lymphomas and neoplasies ++ ++
Reactivation in transplants ++ ++
Reactivation in AIDS ++ ++
Tissue distribution
Peripheral blood mononuclear cells + +++
Salivary glands _ ++++
Skin ++ ++
Brain ++ ++
Lymph nodes _ ++++
Other tissues _ ++++
Serum from healthy persons _ _
Serum from exanthem subitum patients _ ++++
Serum from other patientsc +++ +
Saliva _ ++++
Cerebrospinal fluid +++ +

aDifferent degrees of HHV-6 positivity.
bException, Zambian children, 44% variant A.
cPatients with AIDS, chronic fatigue syndrome, and lymphomas.

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