Volume 5, Number 3—June 1999
Synopsis
Human Herpesvirus 6: An Emerging Pathogen
Gabriella Campadelli-Fiume
, Prisco Mirandola, and Laura Menotti
, Prisco Mirandola, and Laura MenottiTable
Epidemiology and distribution of human herpesvirus (HHV-6) variants
| Variant | A Variant B | |
|---|---|---|
| Associated pathologic conditions | ||
| Exanthem subitum febrile syndromesb | _a | ++++ |
| Multiple sclerosis | ++ | ++ |
| Lymphomas and neoplasies | ++ | ++ |
| Reactivation in transplants | ++ | ++ |
| Reactivation in AIDS | ++ | ++ |
| Tissue distribution | ||
| Peripheral blood mononuclear cells | + | +++ |
| Salivary glands | _ | ++++ |
| Skin | ++ | ++ |
| Brain | ++ | ++ |
| Lymph nodes | _ | ++++ |
| Other tissues | _ | ++++ |
| Serum from healthy persons | _ | _ |
| Serum from exanthem subitum patients | _ | ++++ |
| Serum from other patientsc | +++ | + |
| Saliva | _ | ++++ |
| Cerebrospinal fluid | +++ | + |
aDifferent degrees of HHV-6 positivity.
bException, Zambian children, 44% variant A.
cPatients with AIDS, chronic fatigue syndrome, and lymphomas.
