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Volume 5, Number 6—December 1999
Research

Serologic Evidence of Human Monocytic and Granulocytic Ehrlichiosis in Israel

Avi Keysary*, Lili Amram†, Gershon Keren‡, Zev Sthoeger§, Israel Potasman¶, Amir Jacob#, Carmella Strenger*, Jacqueline E. Dawson**, and Trevor Waner*Comments to Author 
Author affiliations: *Israel Institute for Biological Research, Ness Ziona, Israel; †Asaf Harofe Medical Center, Tzrifin, Israel; ‡Sheba Medical Center, Tel Hashomer, Israel; §Kaplan Hospital, Rehovot, Israel; ¶Bnei-Zion Medical Center, Haifa, Israel; #Schneider Children's Medical Center of Israel, Petach Tikvah, Israel; and **Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table

Clinical and serologic data for patients in Israel with antibodies to Ehrlichia chaffeensis and the human granulocytic ehrlichiosis agent

Patients
Clinical and serologic data 1 2 3 4 5
Date 7/94 7/94 8/95 2/97 7/97
Sex F F M M M
Age (years) 77 8 22 12 52
IFA titer (HME) 1:128 1:256 1:1,024 1:256 1:256
IFA titer E. canis 1:80 1:80 1:640 <1:40 <1:40
IFA titer (HGE) <1:64 <1:64 1:2,048a <1:64 <1:64
Body temperature (°C) 40 39.2 40.2 40 38.5
Symptoms:

Vomiting - + - -

Headache + ++

Chills + +

Macular rash + + +

Lymphomegaly + +

Neck pain - + - - -

Duration (days) 7 >5 12 14 14
Tetracycline therapy + + + -
Total leukocyte count/µlb 3,700 4,000 3,500 4,000 16,700
Total platelet count/µlc 86,000 272,000 95,000 177,000 318,000

aWestern blot analysis of the serum proved positive for HGE.
bNormal range for total leukocyte count 4,000-10,000/µ l.
HGE, human granulocytic ehrlichiosis; HME, human monocytic ehrlichiosis; IFA, immunofluorescence assay.
cNormal range for total platelet count 150,000-450,000/µl.

Main Article

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