Volume 6, Number 1—February 2000
Perspective
Japanese Encephalitis Immunization in South Korea: Past, Present, and Future
Young Mo Sohn
Table 2
Cases of adverse reactions to Japanese encephalitis vaccine reported to the National Compensation Program for Vaccine Injury, South Korea, 1994
| Case | Age/sex | Previous vaccination | Vaccine strain | Date of vaccination | Date of onset | Symptoms at onset/ sequelae/laboratory findings | Outcome |
|---|---|---|---|---|---|---|---|
| 1 | 5/F | 2 doses of JE | Nakayama | 5/23/94 | 5/23/94 | Anaphylactic shock | Death |
| (Lot 3008) | collapse, cardiac arrest | ||||||
| 2 | 5/M | 2 doses of JE | Nakayama | 5/23/94 | 5/23/94 | Anaphylactic shock | Death |
| (Lot 3008) | collapse, cardiac arrest | ||||||
| 3 | 15/F | 8 doses of JE | Nakayama | 4/4/94 | |||
| (Unknown) | |||||||
| 2 doses of | Hantavax | 4/20/94 | 5/13/94 | Headache, auditory | Death | ||
| HRFS | (Unknown) | hallucination, seizure | |||||
| Brain CT normal | |||||||
| MRI normal | |||||||
| EEG moderate to severe cortical dysfunction, | |||||||
| multifocal generalized | |||||||
| polyspike and slow wave | |||||||
| on both hemispheres | |||||||
| CSF protein (20 mg/dl), glucose (78 mg/dl), | |||||||
| WBC (17/mm3) | |||||||
| 4 | 8/F | >2 doses of JE | Nakayama | 5/7/94 | 5/19/94 | High fever, seizure | Recovery |
| (Lot 0132-93011) | Brain CT normal | ||||||
| EEG compatible with | |||||||
| encephalopathy | |||||||
| CSF protein (82 mg/dl), | |||||||
| glucose (99 mg/dl), | |||||||
| WBC (18/mm3) | |||||||
| 5 | 9/F | >3 doses of JE | Nakayama | 4/24/94 | 5/11/94 | High fever, headache, | Death |
| (Unknown) | vomiting, seizure | ||||||
| Brain CT diffuse brain edema | |||||||
| CSF protein (6 mg/dl), glucose (75 mg/dl), | |||||||
| WBC (10/mm3) | |||||||
| 6 | 2/F | none | Nakayama | 4/11/94 | 4/23/94 | Urinary incontinence, | Mental |
| (Unknown) | drooling, high fever, | retar- | |||||
| motor weakness, | dation | ||||||
| vomiting, cranial nerve | |||||||
| palsy (III,IV,VI) | |||||||
| diplopia and phtosis, | |||||||
| headache, seizure | |||||||
| MRI compatible with acute disseminated encephalomyelitis | |||||||
| 7 | 10/M | >3 doses of JE | Nakayama | 4/23/96 | 5/25/96 | Headache, vomiting, | Death |
| seizure, coma | |||||||
JE, Japanese encephalitis; HFRS, Hemorrhagic fever with renal syndrome; CT, computer-assisted tomography; MRI, magnetic resonance imaging; EEG, electroencephalograph; CSF, cerebrospinal fluid; WBC, white blood cells.
