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Volume 6, Number 1—February 2000


Japanese Encephalitis Immunization in South Korea: Past, Present, and Future

Young Mo SohnComments to Author 
Author affiliation: Yonsei University College of Medicine, Seoul, South Korea

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Table 2

Cases of adverse reactions to Japanese encephalitis vaccine reported to the National Compensation Program for Vaccine Injury, South Korea, 1994

Case Age/sex Previous vaccination Vaccine strain Date of vaccination Date of onset Symptoms at onset/ sequelae/laboratory findings Outcome
1 5/F 2 doses of JE Nakayama 5/23/94 5/23/94 Anaphylactic shock Death
(Lot 3008) collapse, cardiac arrest
2 5/M 2 doses of JE Nakayama 5/23/94 5/23/94 Anaphylactic shock Death
(Lot 3008) collapse, cardiac arrest
3 15/F 8 doses of JE Nakayama 4/4/94
2 doses of Hantavax 4/20/94 5/13/94 Headache, auditory Death
HRFS (Unknown) hallucination, seizure
Brain CT normal
MRI normal
EEG moderate to severe cortical dysfunction,
multifocal generalized
polyspike and slow wave
on both hemispheres
CSF protein (20 mg/dl), glucose (78 mg/dl),
WBC (17/mm3)
4 8/F >2 doses of JE Nakayama 5/7/94 5/19/94 High fever, seizure Recovery
(Lot 0132-93011) Brain CT normal
EEG compatible with
CSF protein (82 mg/dl),
glucose (99 mg/dl),
WBC (18/mm3)
5 9/F >3 doses of JE Nakayama 4/24/94 5/11/94 High fever, headache, Death
(Unknown) vomiting, seizure
Brain CT diffuse brain edema
CSF protein (6 mg/dl), glucose (75 mg/dl),
WBC (10/mm3)
6 2/F none Nakayama 4/11/94 4/23/94 Urinary incontinence, Mental
(Unknown) drooling, high fever, retar-
motor weakness, dation
vomiting, cranial nerve
palsy (III,IV,VI)
diplopia and phtosis,
headache, seizure
MRI compatible with acute disseminated encephalomyelitis
7 10/M >3 doses of JE Nakayama 4/23/96 5/25/96 Headache, vomiting, Death
seizure, coma

JE, Japanese encephalitis; HFRS, Hemorrhagic fever with renal syndrome; CT, computer-assisted tomography; MRI, magnetic resonance imaging; EEG, electroencephalograph; CSF, cerebrospinal fluid; WBC, white blood cells.

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