The bdr Gene Families of the Lyme Disease and Relapsing Fever Spirochetes: Potential Influence on Biology, Pathogenesis, and Evolution
David M. Roberts*, Jason A Carlyon†, Michael Theisen, and Richard T. Marconi*
Author affiliations: *Medical College of Virginia at Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA; †Yale School of Medicine, Yale University, New Haven, Connecticut, USA; ‡Statens Serum Institute, Copenhagen, Denmark
Figure 2. General organization of two bdr loci in Borrelia turicatae and B. burgdorferi. The gene arrangement depicted for B. turicatae was determined through cloning and sequence analysis of a 2,217 base-pair XbaI restriction fragment. The arrangement for the bdr-carrying locus of B. burgdorferi was previously determined through the sequencing of the B. burgdorferi B31 genome (30). The arrows indicate the direction of transcription. Genes exhibiting homology are indicated by similar shading or hatch marks. Genes indicated by unfilled arrows are not homologous. The numbering is indicated for scale and is not indicative of the positioning of these genes on the plasmids that carry them.
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