Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

Volume 6, Number 2—April 2000

Synopsis

Vaccines for Mucosal Immunity to Combat Emerging Infectious Diseases

Frederik W. van GinkelComments to Author , Huan H. Nguyen, and Jerry R. McGhee
Author affiliations: The University of Alabama at Birmingham, Birmingham, Alabama, USA

Main Article

Figure 2

Differentiation and regulation of T-helper subsets and the immune response in the mucosal compartments. Encounter of pathogen-derived antigen or vaccine antigen will stimulate T-helper cells to secrete cytokines. Depending on the stimulus, a Th1 or Th2 cell response is induced. For example, intracellular pathogens will induce production of IL-12/IL-18 by macrophages, activating IFN-gð production by NK cells and inducing differentiation to a Th1-mediated immune response, which supports CMI and pr

Figure 2. Differentiation and regulation of T-helper subsets and the immune response in the mucosal compartments. Encounter of pathogen-derived antigen or vaccine antigen will stimulate T-helper cells to secrete cytokines. Depending on the stimulus, a Th1 or Th2 cell response is induced. For example, intracellular pathogens will induce production of IL-12/IL-18 by macrophages, activating IFN-gð production by NK cells and inducing differentiation to a Th1-mediated immune response, which supports CMI and production of complement-fixing antibodies, presumably by production of cytokines such as IFN-gð, IL-2, and TNF-bð. A Th2 response can be observed upon infection with parasites or upon vaccine administration; this response is characterized by production of cytokines such as IL-4, IL-5, IL-6, IL-10, IL-13 which support humoral immunity. However, for induction of a S-IgA, TGF-bð1 is required to enable B cells to switch to IgA. TGF-bð1 production is associated with inhibition of IL-4 production by Th2 cells inhibiting IgE production.

Main Article

Top of Page

 

Past Issues

Select a Past Issue:

Art in Science - Selections from Emerging Infectious Diseases
Now available for order



CDC 24/7 – Saving Lives, Protecting People, Saving Money. Learn More About How CDC Works For You…

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO