Volume 6, Number 2—April 2000
Dispatch
Sin Nombre Virus (SNV) Ig Isotype Antibody Response during Acute and Convalescent Phases of Hantavirus Pulmonary Syndrome
Pavel Bostik*, Jorn Winter*†, Thomas G. Ksiazek†, Pierre E. Rollin†, Francois Villinger*, Sherif R. Zaki†, C.J. Peters†, and Aftab A. Ansari*
Table
Total Ig concentrations and specific Sin Nombre virus Ig titers in sera from patients with hantavirus pulmonary syndrome
| Patienta | Daysb | IgM | IgG1 | IgG2 | IgG3 | IgG4 | IgA | Total IgM [mg/dl] | Total IgG [mg/dl] | Total IgA [mg/dl] | Phase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 7(d)c | 1 | 25,600 | 400 | 0 | 1,600 | 0 | 25,600 | 264 | 1,000 | 336 | Acute |
| 8(d) | 1 | 1,600 | 0 | 0 | 100 | 0 | 0 | 559 | <333 | <67 | Acute |
| 9(d) | 1 | 25,600 | 400 | 0 | 6,400 | 0 | 102,400 | 295 | 802 | <40 | Acute |
| 6.1 | 2 | 102,400 | 6,400 | 100 | 25,600 | 0 | 25,600 | 280 | 1,590 | 492 | Acute |
| 10(d) | 2 | 25,600 | 100 | 0 | 400 | 0 | 0 | ndd | 4,840 | 234 | Acute |
| 5.1 | 2 | 25,600 | 100 | 0 | 1,600 | 0 | 409,600 | 1,080 | 176 | 342 | Acute |
| 21.1 | 4 | 102,400 | 100 | 6,400 | 409,600 | 0 | 0 | 409,600 | nd | nd | Acute |
| 23.1 | 7 | 25,600 | 100 | 100 | 400 | 0 | 25,600 | nd | nd | nd | Acute |
| 1.1 | 7 | 1,600 | 400 | 100 | 6,400 | 0 | 400 | 142 | 401 | 108 | Acute |
| 11(d) | 7 | 102,400 | 100 | 0 | 400 | 0 | 6,400 | nd | nd | nd | Acute |
| 23.2 | 8 | 25,600 | 0 | 0 | 100 | 0 | 0 | nd | nd | nd | Acute |
| 12(d) | 8 | 6,400 | 0 | 0 | 0 | 0 | 0 | 108 | <381 | <67 | Acute |
| 4.3 | 10 | 6,400 | 0 | 0 | 1,600 | 0 | 25,600 | nd | nd | nd | Early conv.e |
| 2.1 | 12 | 25,600 | 6,400 | 1,600 | 25,600 | 0 | 409,600 | 225 | 508 | 125 | Early conv. |
| 21.2 | 13 | 102,400 | 100 | 6,400 | 409,600 | 100 | 409,600 | nd | nd | nd | Early conv. |
| 23.3 | 13 | 6,400 | 0 | 0 | 100 | 0 | 100 | nd | nd | nd | Early conv. |
| 3.1 | 16 | 6,400 | 6,400 | 100 | 6,400 | 0 | 0 | 322 | 1,170 | 290 | Early conv. |
| 1.2 | 21 | 25,600 | 6,400 | 400 | 25,600 | 0 | 0 | nd | nd | nd | Early conv. |
| 4.1 | 24 | 1,600 | 0 | 0 | 6,400 | 0 | 6,400 | nd | nd | nd | Early conv. |
| 13 | 24 | 0 | 6,400 | 0 | 102,400 | 0 | 102,400 | nd | nd | nd | Early conv. |
| 14 | 30 | 1,600 | 0 | 0 | 1,600 | 0 | 100 | nd | nd | nd | Early conv. |
| 15 | 34 | 0 | 100 | 0 | 6,400 | 0 | 0 | 201 | 1,400 | 263 | Late conv. |
| 3.2 | 35 | 0 | 6,400 | 0 | 6,400 | 0 | 0 | 176 | 2,110 | 221 | Late conv. |
| 4.2 | 59 | 0 | 0 | 0 | 1,600 | 0 | 1,600 | 144 | 1,310 | 95 | Late conv. |
| 2.2 | 66 | 0 | 1,600 | 100 | 6,400 | 0 | 0 | 126 | 1,140 | 140 | Late conv. |
| 16 | 66 | 0 | 100 | 0 | 25,600 | 0 | 0 | 69 | 977 | 82 | Late conv. |
| 20.2 | 67 | 0 | 400 | 100 | 6,400 | 0 | 100 | nd | nd | nd | Late conv. |
| 6.2 | 67 | 25,600 | 6,400 | 0 | 102,400 | 0 | 100 | 219 | 1,700 | 403 | Late conv. |
| 17.1 | 92 | 0 | 100 | 0 | 102,400 | 0 | 0 | 107 | 1,000 | 162 | Late conv. |
| 5.2 | 145 | 0 | 100 | 0 | 1,600 | 0 | 0 | 78 | 1,260 | 288 | Late conv. |
| 18 | 330 | 0 | 100 | 0 | 25,600 | 0 | 0 | nd | nd | nd | Late conv. |
| 17.2 | 330 | 0 | 100 | 0 | 6,400 | 0 | 0 | nd | nd | nd | Late conv. |
| 19 | 547 | 0 | 100 | 0 | 400 | 0 | 0 | nd | nd | nd | Late conv. |
aDecimal values indicate sequential samples from one patient.
bDays after patient reported to hospital.
c(d) = patient died.
dnd = not done.
econv. = convalescent.
