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Volume 6, Number 2—April 2000

Dispatch

Sin Nombre Virus (SNV) Ig Isotype Antibody Response during Acute and Convalescent Phases of Hantavirus Pulmonary Syndrome

Pavel Bostik*, Jorn Winter*†, Thomas G. Ksiazek†, Pierre E. Rollin†, Francois Villinger*, Sherif R. Zaki†, C.J. Peters†, and Aftab A. Ansari*Comments to Author 
Author affiliations: *Emory University School of Medicine, Atlanta, Georgia, USA; and †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

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Table

Total Ig concentrations and specific Sin Nombre virus Ig titers in sera from patients with hantavirus pulmonary syndrome

Patienta Daysb IgM IgG1 IgG2 IgG3 IgG4 IgA Total IgM [mg/dl] Total IgG [mg/dl] Total IgA [mg/dl] Phase
7(d)c 1 25,600 400 0 1,600 0 25,600 264 1,000 336 Acute
8(d) 1 1,600 0 0 100 0 0 559 <333 <67 Acute
9(d) 1 25,600 400 0 6,400 0 102,400 295 802 <40 Acute
6.1 2 102,400 6,400 100 25,600 0 25,600 280 1,590 492 Acute
10(d) 2 25,600 100 0 400 0 0 ndd 4,840 234 Acute
5.1 2 25,600 100 0 1,600 0 409,600 1,080 176 342 Acute
21.1 4 102,400 100 6,400 409,600 0 0 409,600 nd nd Acute
23.1 7 25,600 100 100 400 0 25,600 nd nd nd Acute
1.1 7 1,600 400 100 6,400 0 400 142 401 108 Acute
11(d) 7 102,400 100 0 400 0 6,400 nd nd nd Acute
23.2 8 25,600 0 0 100 0 0 nd nd nd Acute
12(d) 8 6,400 0 0 0 0 0 108 <381 <67 Acute
4.3 10 6,400 0 0 1,600 0 25,600 nd nd nd Early conv.e
2.1 12 25,600 6,400 1,600 25,600 0 409,600 225 508 125 Early conv.
21.2 13 102,400 100 6,400 409,600 100 409,600 nd nd nd Early conv.
23.3 13 6,400 0 0 100 0 100 nd nd nd Early conv.
3.1 16 6,400 6,400 100 6,400 0 0 322 1,170 290 Early conv.
1.2 21 25,600 6,400 400 25,600 0 0 nd nd nd Early conv.
4.1 24 1,600 0 0 6,400 0 6,400 nd nd nd Early conv.
13 24 0 6,400 0 102,400 0 102,400 nd nd nd Early conv.
14 30 1,600 0 0 1,600 0 100 nd nd nd Early conv.
15 34 0 100 0 6,400 0 0 201 1,400 263 Late conv.
3.2 35 0 6,400 0 6,400 0 0 176 2,110 221 Late conv.
4.2 59 0 0 0 1,600 0 1,600 144 1,310 95 Late conv.
2.2 66 0 1,600 100 6,400 0 0 126 1,140 140 Late conv.
16 66 0 100 0 25,600 0 0 69 977 82 Late conv.
20.2 67 0 400 100 6,400 0 100 nd nd nd Late conv.
6.2 67 25,600 6,400 0 102,400 0 100 219 1,700 403 Late conv.
17.1 92 0 100 0 102,400 0 0 107 1,000 162 Late conv.
5.2 145 0 100 0 1,600 0 0 78 1,260 288 Late conv.
18 330 0 100 0 25,600 0 0 nd nd nd Late conv.
17.2 330 0 100 0 6,400 0 0 nd nd nd Late conv.
19 547 0 100 0 400 0 0 nd nd nd Late conv.

aDecimal values indicate sequential samples from one patient.
bDays after patient reported to hospital.
c(d) = patient died.
dnd = not done.
econv. = convalescent.

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