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Volume 6, Number 4—August 2000

Research

Reemergence of Pertussis in the Highly Vaccinated Population of The Netherlands: Observations on Surveillance Data

Hester E. de MelkerComments to Author , J.F.P. Schellekens, S.E. Neppelenbroek, F.R. Mooi, H.C. Rümke, and M.A.E. Conyn-van Spaendonck
Author affiliations: National Institute of Public Health and the Environment, Bilthoven, the Netherlands

Main Article

Table 1

Reported cases, hospitalizations, ratios of reported cases to hospitalizations, positive 2-point serology and positive 1-point serology, 1976-1998

Yr Reports Hosps Pos, 2-point test Pos, 1-point test Ratio of reports/hosps Ratio of reports/pos.2-point test Ratio of reports/pos.1-point test
1976a 4 52 NA NA 0.1 NA NA
1977 25 93 NA NA 0.3 NA NA
1978 1 32 NA NA 0.0 NA NA
1979 26 43 NA NA 0.6 NA NA
1980 30 65 NA NA 0.5 NA NA
1981b 50 76 NA NA 0.7 NA NA
1982 80 98 NA NA 0.8 NA NA
1983 200 223 NA NA 0.9 NA NA
1984c 534 200 NA NA 2.7 NA NA
1985 1522 313 NA NA 4.9 NA NA
1986 2159 388 NA 2717 5.6 NA 0.8
1987 2709 474 NA 3295 5.7 NA 0.8
1988d 112 92 NA NA 1.2 NA NA
1989 523 221 350 1760 2.4 1.5 0.3
1990 397 157 278 1204 2.5 1.4 0.3
1991 145 82 110 411 1.8 1.3 0.4
1992 160 101 238 861 1.6 0.7 0.2
1993 346 288 482 1489 1.2 0.7 0.2
1994 519 276 498 1867 1.9 1.0 0.3
1995 341 162 272 1070 2.1 1.3 0.3
1996 4231 513 1885 7854 8.2 2.2 0.5
1997e 2671 436 924 4107 6.1 2.9 0.7
1998f 1582 NA 294 2187 NA 5.4 0.7

aMandatory case reporting introduced.
bIgA assay introduced.
cIgG assay introduced.
dCase definition for reporting (including strict criteria for interpretation of serologic tests) introduced.
eFormal acceptance of positive one-point serologic test.
fData from January to September 1998.
1-point test = cases with one-point serology; 2-point test = cases with two-point serology; NA=not available.

Main Article

1Vaccine effectiveness = 1 – (proportion of vaccinated cases/1 – proportion of vaccinated cases) X (1 – proportion vaccinated in the population/proportion vaccinated in the population).

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