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Volume 6, Number 5—October 2000

Synopsis

Antigenic Variation in Vector-Borne Pathogens

Alan G. Barbour*Comments to Author  and Blanca I. Restrepo†

Author affiliations: *University of California Irvine, Irvine, California; and †Corporación para Investigaciones Biológicas, Medellín, Colombia

Article in Chinese

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Table

Vector-borne infections with antigenic variation

Disease Pathogen(s) Vector Variable antigensa
Relapsing fever Several species of Borrelia, Soft (argasid) ticks Vlp & Vsp
e.g., B. hermsii and body lice
Anaplasmosis Anaplasma marginale Hard (ixodid) ticks MSP2
African trypanosomiasis African Trypanosoma spp., Tsetse fly VSG
e.g., T. brucei
Malaria Plasmodium falciparum Mosquitoes PfEMP1
Babesiosis Babesia bovis Hard (ixodid) ticks VESA1

aVlp = variable large proteins; Vsp = variable small proteins; MSP2 = major surface protein 2; VSG = variant-specific glycoprotein; MfEMP1 = P. falciparum erythrocyte membrane protein 1; VESA1 = variant erythrocyte surface antigen 1.

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