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Volume 7, Number 1—February 2001

Research

Lack of Evidence of Endogenous Avian Leukosis Virus and Endogenous Avian Retrovirus Transmission to Measles Mumps Rubella Vaccine Recipients

Althaf I. Hussain*, Vedapuri Shanmugam*, William M. Switzer*, Shirley X. Tsang*, Aly Fadly†, Donald Thea‡, Rita Helfand*, William J. Bellini*, Thomas M. Folks*, and Walid Heneine*Comments to Author 
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Avian Disease and Oncology Laboratory, U.S. Department of Agriculture, East Lansing, Michigan, USA; ‡Harvard Institute for International Development, Cambridge, Massachusetts, USA

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Table

Western blot antibody reactivity to the p27 gag protein of the endogenous avian leukosis virus (ALV) in vaccine recipients and other reference chicken and human sera

Sera tested p27 Positive
Chicken sera (n = 61)
     ALV infected/antibody positivea 27/27
     ALV uninfected/antibody negativea 0/34
     REVb infected 0/10
Human sera (n = 68)
     Blood donors 0/60
     HIV-1/2b positive 0/4
     HTLV-I/IIb positive 0/4
MMRb vaccine recipients (n = 206)
     6-12 monthsc 0/32
     12-30 monthsc 0/158
     6-12 monthsd 0/16

aantibody reactivity to ALV determined by virus neutralization assays.
bREV = reticuloendotheliosis virus; HIV-1/2 = human immunodeficiency virus type 1 or 2; HTLV-I/II = human T-cell lymphotropic virus type 1 or 2; MMR = measles, mumps and rubella.
csamples collected after first MMR vaccination.
dsamples collected after second MMR vaccination.

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