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Volume 7, Number 6—December 2001

Research

Advanced Age a Risk Factor for Illness Temporally Associated with Yellow Fever Vaccination

Michael Martin*†, Leisa H. Weld*, Theodore F. Tsai*, Gina T. Mootrey*, Robert T. Chen*, Manette Niu‡, Martin S. Cetron*, and the GeoSentinel Yellow Fever Working Group
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;; †Emory School of Medicine, Atlanta, Georgia, USA;; ‡Center for Biologic Evaluation, U.S. Food and Drug Administration, Rockville, Maryland, USA

Main Article

Table 4

Reporting rates (RR) and reporting rate ratios (RRR) for hepatitis A vaccine adverse events by age, 1995-1998

Age (years) No. HAa doses No. OAEb OAE reports/ 100,000 doses RRR (95% CI) No. SyAEc SyAE reports/ 100,000 doses RRR (95% CI)
15-24 387,031 21 5.43 1.8(1.1-3.0) 7 1.81 0.7 (0.3-1.6)
25-44 1,444,895 44 3.05 Ref. 36 2.49 Ref.
45-64 1,096,391 23 2.10 0.7 (0.4-1.1) 26 2.37 1.0 (0.6-1.6)
65-74 241,453 4 1.66 0.5 (0.2-1.5) 15 6.21 2.5(1.4-4.6)
75 61,760 1 1.62 0.5 (0.1-3.9) 3 4.86 1.9 (0.6-6.3)
Total 3,231,530 93 2.88 87 2.69

aHA = hepatitis A [vaccine]; CI = confidence intervals; OAE = other adverse events; SyAE = systemic adverse events; Ref = reference.
bUncomplicated neurologic/systemic, hypersensitivity, or local reaction.
cMultisystemic (excluding anaphylactic) or neurologic reaction.

Main Article

1Jeff Altman, University of Washington, Seattle, Washington; Vernon Ansdell, Kaiser Permanente, Honolulu, Hawaii; Elizabeth Barnett, Boston University, Boston, Massachusetts; Michele Barry Yale University, New Haven, Connecticut; Bradley Connor, Cornell University, New York, New York; David Freedman, University of Alabama at Birmingham, Birmingham, Alabama; Alejandra Gurtman, Mount Sinai Medical Center, New York, New York; Elaine Jong, University of Washington, Seattle, Washington; Phyllis Kozarsky, Emory University, Atlanta, Georgia; Russell McMullen, University of Washington, Seattle, Washington; Jan Patterson, University of Texas, San Antonio, Texas; Bradley Sack, Johns Hopkins University, Baltimore, Maryland; Mary E. Wilson, Harvard University, Cambridge, Massachusetts; Martin Wolfe, Traveler's Medical Service of Washington, Washington, D.C.

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