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Volume 8, Number 11—November 2002

Research

Tuberculosis-Related Deaths within a Well-Functioning DOTS Control Program

Maria de Lourdes García-García*, Alfredo Ponce-de-León†, Maria Cecilia García-Sancho‡, Leticia Ferreyra-Reyes*, Manuel Palacios-Martínez*, Javier Fuentes§, Midori Kato-Maeda†, Miriam Bobadilla†, Peter Small¶, and Jose Sifuentes-Osornio†
Author affiliations: *Instituto Nacional de Salud Pública, Cuernavaca, México; †Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán,” México City, México; ‡Instituto Nacional de Enfermedades Respiratorias, México City, Mexico; §Secretaría de Salud del Estado de Veracruz, Xalapa, México; ¶Stanford University, Palo Alto, California, USA;

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Table 2

Population attributable-risk percent and hazard ratios for death among smear-positive tuberculosis (TB) patients, Orizaba, Veracruz, 1995–2000a

Variables Population attributable risk (%) Adjusted
hazard ratio 95% CI p valueb
Death due to TBc
Treatment default 28.7 8.9 3.3 to 24.4 <0.0001
Resistance to isoniazid and rifampin 25.9 5.7 2.0 to 16.3 <0.001
Clustered 18.8 4.1 1.6 to 10.0 0.002
Weight loss (>15%) 3.9 1.5 to 10.9 0.007
Formal education <6 yr 1.8 0.6 to 5.2 0.3
Death due to other causes
HIV/AIDS 11.1 33.1 11.4 to 95.4 <0.0001
Hepatic cirrhosis 6.6 5.7 1.6 to 19.7 0.006
Weight loss (>15% ) 3.3 1.6 to 6.7 0.001
Age (yrs) 1.02 0.99 to 1.04 0.07

aCI, confidence interval; —, not applicable.
bCox proportional hazards model.
cControlling for death before or after treatment completion, default or failure.

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